Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier

doi:10.1002/anie.200803526

Residential College	false
Status	已發表Published
	Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier
	Wang Y.-Y.; Lai S.K.; Suk J.S.; Pace A.; Cone R.; Hanes J.
	2008-12-01
Source Publication	Angewandte Chemie - International Edition
ISSN	14337851
Volume	47 Issue:50 Pages:9726-9729
Abstract	(Figure Presented) Outsmarting the barrier: Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by adhesive interactions (red) with the mucus mesh (black lines). A dense, low molecular weight PEG coating (blue) uniquely endows nanoparticles with a mucoinert surface that enables their rapid mucus penetration (trajectory indicated by grey line). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
Keyword	Drug Delivery Mucosal Tissues Nanomedicine Particle Tracking Surface Chemistry
DOI	10.1002/anie.200803526
URL	View the original
Language	英語English
WOS ID	WOS:000261727400026
Scopus ID	2-s2.0-57049085726
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	Johns Hopkins University
Recommended Citation GB/T 7714	Wang Y.-Y.,Lai S.K.,Suk J.S.,et al. Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier[J]. Angewandte Chemie - International Edition, 2008, 47(50), 9726-9729.
APA	Wang Y.-Y.., Lai S.K.., Suk J.S.., Pace A.., Cone R.., & Hanes J. (2008). Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier. Angewandte Chemie - International Edition, 47(50), 9726-9729.
MLA	Wang Y.-Y.,et al."Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier".Angewandte Chemie - International Edition 47.50(2008):9726-9729.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh