Effect of apoptotic ovarian cancer cells induced by paclitaxel-cisplatin on antigen presentation function of DC

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	Effect of apoptotic ovarian cancer cells induced by paclitaxel-cisplatin on antigen presentation function of DC
	Feng Q.M.; Wu X.; Wang Y.; Ge H.L.; Di W.
	2009
Source Publication	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
ISSN	10078738
Volume	25 Issue:1 Pages:38-41
Abstract	AIM: To explore wheather apoptotic ovarian cancer cells induced by paclitaxel-cisplatin could be cross-presented by antigen presenting cells and promote immune responses. METHODS: DCs were generated from peripheral blood monocytes in RPMI1640 supplemented with GM-CSF and IL-4. After 6 days' incubation, DCs were further co-cultured with either apoptotic HO8910 cell lines induced by paclitaxel-cisplatin or control cells for four hours. Maturation of DCs was compared among different groups according to their surface markers through flow cytometry assay and their phagocytosis ability was evaluated by confocal microscopy scanning assay. RESULTS: Apoptotic ovarian cancer cells induced by paclitaxel-cisplatincan were phagocytized more efficiently by DCs.Resulting is more cellularity and maturation of DCs in apoptotic cell-induced groups than control group (P<0.05). CONCLUSION: Apoptotic ovarian cancer cells induced by paclitaxel-cisplatin exhibit strong immunogenicity, which in turn promote the maturation and antigen presentation of DCs.
URL	View the original
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Journal article
Collection	University of Macau
Affiliation	Renji Hospital
Recommended Citation GB/T 7714	Feng Q.M.,Wu X.,Wang Y.,et al. Effect of apoptotic ovarian cancer cells induced by paclitaxel-cisplatin on antigen presentation function of DC[J]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2009, 25(1), 38-41.
APA	Feng Q.M.., Wu X.., Wang Y.., Ge H.L.., & Di W. (2009). Effect of apoptotic ovarian cancer cells induced by paclitaxel-cisplatin on antigen presentation function of DC. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 25(1), 38-41.
MLA	Feng Q.M.,et al."Effect of apoptotic ovarian cancer cells induced by paclitaxel-cisplatin on antigen presentation function of DC".Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 25.1(2009):38-41.

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