| Residential College | false |
| Status | 已發表Published |
| CTSS promoter -25G/A: not a risk factor for CHD in Chinese. | |
| Sun A.; Binay K.R.; Xiang F.; Zhao J.; Wang Y.; Xu L.; Ma H.; Wang K.; Zou Y.; Huang W.; Ge J. | |
| 2009-06-01 | |
| Source Publication | Acta cardiologica
 |
| ISSN | 00015385 |
| Volume | 64Issue:3Pages:393-396 |
| Abstract | OBJECTIVE: Atherosclerosis is an inflammatory disease characterized by extensive remodelling of the extracellular matrix architecture of the arterial wall. Recent data suggested the participation of lysosomal cysteine proteases such as cathepsin S (CTSS) in atherogenesis. The G/A polymorphism at nucleotide -25 was reported to be located in the promoter of the CTSS gene. The aim of this study was to observe the association between CTSS -25G/A polymorphism and the risk of coronary heart disease (CHD) in a Chinese population sample. METHODS: The polymerase chain reaction and restriction digestion methods were performed to screen the CTSS gene -25G/A polymorphism in a Chinese population sample with (n = 659) or without CHD (n = 352). Traditional risk factors for CHD were obtained simultaneously. RESULTS: The frequencies of the G and A allele in the total population was 0.630 and 0.370, respectively. The frequencies of -25G/A polymorphism in the CTSS gene (G: 0.626 vs. 0.633, P > 0.05; A: 0.374 vs. 0.367, P > 0.05) and the genotype distribution (G: 83.4 vs. 85.3, P > 0.05; A: 58.0 vs. 58.5, P > 0.05) were similar between CHD patients and control subjects. Moreover, CTSS genotype was not associated with severity of coronary stenosis (P > 0.05) in CHD patients. CONCLUSION: The CTSS -25G/A polymorphism was not related with CHD in our Chinese population sample. |
| URL | View the original |
| Language | 英語English |
| Fulltext Access | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | Fudan University |
| Recommended Citation GB/T 7714 | Sun A.,Binay K.R.,Xiang F.,et al. CTSS promoter -25G/A: not a risk factor for CHD in Chinese.[J]. Acta cardiologica, 2009, 64(3), 393-396. |
| APA | Sun A.., Binay K.R.., Xiang F.., Zhao J.., Wang Y.., Xu L.., Ma H.., Wang K.., Zou Y.., Huang W.., & Ge J. (2009). CTSS promoter -25G/A: not a risk factor for CHD in Chinese.. Acta cardiologica, 64(3), 393-396. |
| MLA | Sun A.,et al."CTSS promoter -25G/A: not a risk factor for CHD in Chinese.".Acta cardiologica 64.3(2009):393-396. |
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