From Myristica fragrans L. (Myristicaceae) two spices, nutmeg and mace, were obtained. This plant is traditionally used in China, India, and African countries for the treatment of several diseases, such as decreased appetite, diarrhea, muscle spasm, rheumatism, etc. Recently, M. fragrans has been investigated for antioxidant, anticonvulsant, analgesic, anti-inflammatory, antidiabetic, hypolipidemic and hypocholesterolemic, antibacterial, and antifungal potential. A perusal analysis of literature evidenced that M. fragrans deserves more attention by scientific community to explore its full range of bioactivity in the welfare of the society especially in emergent Countries.