C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4

doi:10.1016/j.bbrc.2011.05.047

Residential College	false
Status	已發表Published
	C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4
	Zhang Y.2; Tian L.2; Zheng Y.2; Qi H.2; Guo C.2; Sun Q.2; Xu E.2; Zhang Y.2; Ma D.2; Wang Y.2
	2011-06-03
Source Publication	Biochemical and Biophysical Research Communications
ISSN	0006291X 10902104
Volume	409 Issue:2 Pages:356-361
Abstract	CKLF1, a human cytokine that is a functional ligand for CCR4, is upregulated in various inflammation and autoimmune diseases. CKLF1 contains at least two secreted forms, the C-terminal peptides C19 and C27. Chemically synthesized C19 and C27 can interact with CCR4 and attenuate allergic inflammation. In this study, we found C19 and C27 could inhibit SDF-1-induced CXCR4-mediated chemotaxis and promote CXCR4 internalization. The inhibitory effect was due to desensitization of CXCR4, which was mediated by CCR4. Further experiments confirmed that CXCR4 desensitization required activation of PI3K/PKC pathway. Altogether our data elucidate the mechanism of C19- and C27-induced CXCR4 desensitization. © 2011 Elsevier Inc.
Keyword	Ccr4 Cklf1 Cxcr4 Desensitization Peptide Pkc
DOI	10.1016/j.bbrc.2011.05.047
URL	View the original
Language	英語English
WOS ID	WOS:000291779100036
Scopus ID	2-s2.0-79957902152
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Peking University Health Science Center 2.Peking University
Recommended Citation GB/T 7714	Zhang Y.,Tian L.,Zheng Y.,et al. C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4[J]. Biochemical and Biophysical Research Communications, 2011, 409(2), 356-361.
APA	Zhang Y.., Tian L.., Zheng Y.., Qi H.., Guo C.., Sun Q.., Xu E.., Zhang Y.., Ma D.., & Wang Y. (2011). C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4. Biochemical and Biophysical Research Communications, 409(2), 356-361.
MLA	Zhang Y.,et al."C-terminal peptides of chemokine-like factor 1 signal through chemokine receptor CCR4 to cross-desensitize the CXCR4".Biochemical and Biophysical Research Communications 409.2(2011):356-361.

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