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Patent NumberCN105968210B
Status已授權 Granted
靶向CD22的强杀伤性嵌合抗原受体T细胞及其在制备治疗肿瘤的药物中的用途
Year Issued2019
2019-05-31
Application NumberZL201610318870.2
Application Date2016-05-13
Rights Holder深圳生创精准医疗科技有限公司
赵琦; 刘遥; 项春生; 李程
Date Available2019-05-31
Country中国 China
Subtype发明专利 Invention
Abstract

本发明提供了一种抗CD22嵌合抗原受体,其中,该抗CD22嵌合抗原受体的氨基酸序列包括SEQ ID NO.1所示的序列,并且,该抗CD22嵌合抗原受体能够识别CD22蛋白且能够在识别CD22蛋白后活化酪氨酸信号通路。本发明还提供了如上所述的抗CD22嵌合抗原受体的编码核酸、表达载体、细胞、药物组合物和它们的用途。通过上述技术方案,本发明的表达抗CD22嵌合抗原受体的T淋巴细胞针对表达CD22的肿瘤细胞具有高度特异性的细胞毒性作用和非常强的杀伤能力。

Language中文Chinese
Open (Notice) NumberCN105968210B
IPC Classification NumberC07k19/00 ; C12n15/62 ; C12n15/867 ; C12n5/10 ; A61k35/17 ; A61p35/00
CPC Classification NumberC07k2319/02 ; C12n15/86 ; C07k16/2803 ; C12n2740/15043 ; A61k35/17 ; C12n2510/00 ; C12n2800/107 ; C07k14/70596 ; C12n5/0636
Patent Agent耿超 ; 王浩然
Agency北京英创嘉友知识产权代理事务所(普通合伙) 11447
Document TypePatent
CollectionFaculty of Health Sciences
Recommended Citation
GB/T 7714
赵琦,刘遥,项春生,等. 靶向CD22的强杀伤性嵌合抗原受体T细胞及其在制备治疗肿瘤的药物中的用途. CN105968210B[P]. 2019-05-31.
APA 赵琦., 刘遥., 项春生., & 李程 (2016-05-13). 靶向CD22的强杀伤性嵌合抗原受体T细胞及其在制备治疗肿瘤的药物中的用途.
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