Protective effect of r-sHSA on acute hepatic injury induced by CCl 4 in mice

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	Protective effect of r-sHSA on acute hepatic injury induced by CCl 4 in mice
	Hang Y.-F.; Zhang X.-Y.; Xue X.-Y.; Wang Y.; Ye B.-P.; Ding X.-S.
	2011-10-01
Source Publication	Pharmaceutical Biotechnology
ISSN	10058915
Volume	18 Issue:5 Pages:438-440
Abstract	To investigate the protective effects of recombinant shark hepatical stimulator analogue (r-sHSA) on acute hepatic injury induced by carbon tetrachloride (CCl) in mice, the acute liver-injury model of ICR mice induced by CCl was established by a single intraperitoneal injection of CCl(0.15%) at a dose of 20 mg/kg body weight. Serum ALT and AST activities were analyzed. Histopathological changes in the liver were also examined. The results showed r-sHSA could significantly decrease the activities of mouse serum ALT and AST caused by CCl, recuperate AST/ALT ratio and reduce the content of MDA. Hepatic histological examination showed that r-sHSA could reduce the injury to liver tissue. r-sHSA has a protective effect on acute liver injury by CCl in mice.
Keyword	CCl4 Protective effect r-sHSA
URL	View the original
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Journal article
Collection	University of Macau
Affiliation	China Pharmaceutical University
Recommended Citation GB/T 7714	Hang Y.-F.,Zhang X.-Y.,Xue X.-Y.,et al. Protective effect of r-sHSA on acute hepatic injury induced by CCl 4 in mice[J]. Pharmaceutical Biotechnology, 2011, 18(5), 438-440.
APA	Hang Y.-F.., Zhang X.-Y.., Xue X.-Y.., Wang Y.., Ye B.-P.., & Ding X.-S. (2011). Protective effect of r-sHSA on acute hepatic injury induced by CCl 4 in mice. Pharmaceutical Biotechnology, 18(5), 438-440.
MLA	Hang Y.-F.,et al."Protective effect of r-sHSA on acute hepatic injury induced by CCl 4 in mice".Pharmaceutical Biotechnology 18.5(2011):438-440.

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