This chapter explores Liu Shu-hsien’s philosophy. Given his concern for human cultural development, Liu started his exploration with philosophy of culture. Diagnosing the problem of the present culture as one of our heart-mind’s losing its own way, Liu found a reconceptualization of philosophy necessary. He then constructed, with a creative use of Chinese philosophy, a systematic philosophy to explain value and significance and assign different realms of life their appropriate places. Under this enterprise, Liu suggested the possibility of a global ethic and interreligious dialogue. The idea of “one pattern, many manifestations” he abstracted from Song-Ming Neo-Confucianism is the focus. After an examination of this enterprise, this chapter discusses his contributions to the study of Chinese philosophy.