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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Ricketts C.J.1; De Cubas A.A.20; Fan H.5; Smith C.C.8; Lang M.1; Reznik E.17; Bowlby R.4; Gibb E.A.4; Akbani R.14; Beroukhim R.6; Bottaro D.P.1; Choueiri T.K.13; Gibbs R.A.9; Godwin A.K.16; Haake S.20; Hakimi A.A.17; Henske E.P.10; Hsieh J.J.15; Ho T.H.19; Kanchi R.S.14; Krishnan B.8; Kwaitkowski D.J.10; Lui W.14; Merino M.J.1; Mills G.B.14; Myers J.2; Nickerson M.L.1; Reuter V.E.17; Schmidt L.S.1; Shelley C.S.3; Shen H.5; Shuch B.12; Signoretti S.13; Srinivasan R.1; Tamboli P.14; Thomas G.11; Vincent B.G.8; Vocke C.D.1; Wheeler D.A.9; Yang L.18; Kim W.T.8; Robertson A.G.4; Caesar-Johnson S.J.; Demchok J.A.; Felau I.; Kasapi M.; Ferguson M.L.; Hutter C.M.; Sofia H.J.; Tarnuzzer R.; Wang Z.; Zenklusen J.C.; Zhang J.J.; Chudamani S.; Liu J.; Lolla L.; Naresh R.; Pihl T.; Sun Q.; Wan Y.; Wu Y.; Cho J.; DeFreitas T.; Frazer S.; Gehlenborg N.; Getz G.; Heiman D.I.; Kim J.; Lawrence M.S.; Lin P.; Meier S.; Noble M.S.; Saksena G.; Voet D.; Zhang H.; Bernard B.; Chambwe N.; Dhankani V.; Knijnenburg T.; Kramer R.; Leinonen K.; Liu Y.; Miller M.; Reynolds S.; Shmulevich I.; Thorsson V.; Zhang W.; Broom B.M.; Hegde A.M.; Ju Z.; Korkut A.; Li J.; Liang H.; Ling S.; Liu W.; Lu Y.; Ng K.-S.; Rao A.; Ryan M.; Wang J.; Weinstein J.N.; Zhang J.; Abeshouse A.; Armenia J.; Chakravarty D.; Chatila W.K.; de Bruijn I.; Gao J.; Gross B.E.; Heins Z.J.; Kundra R.; La K.; Ladanyi M.; Luna A.; Nissan M.G.; Ochoa A.; Phillips S.M.; Sanchez-Vega F.; Sander C.; Schultz N.; Sheridan R.; Sumer S.O.; Sun Y.; Taylor B.S.; Anur P.; Peto M.; Spellman P.; Benz C.; Stuart J.M.; Wong C.K.; Yau C.; Hayes D.N.; Parker J.S.; Wilkerson M.D.; Ally A.; Balasundaram M.; Brooks D.; Carlsen R.; Chuah E.; Dhalla N.; Holt R.; Jones S.J.M.; Kasaian K.; Lee D.; Ma Y.; Marra M.A.; Mayo M.; Moore R.A.; Mungall A.J.; Mungall K.; Robertson A.G.; Sadeghi S.; Schein J.E.; Sipahimalani P.; Tam A.; Thiessen N.; Tse K.; Wong T.; Berger A.C.; Cherniack A.D.; Cibulskis C.; Gabriel S.B.; Gao G.F.; Ha G.; Meyerson M.; Schumacher S.E.; Shih J.; Kucherlapati M.H.; Kucherlapati R.S.; Baylin S.; Cope L.; Danilova L.; Bootwalla M.S.; Lai P.H.; Maglinte D.T.; Van Den Berg D.J.; Weisenberger D.J.; Auman J.T.; Balu S.; Bodenheimer T.; Fan C.; Hoadley K.A.; Hoyle A.P.; Jefferys S.R.; Jones C.D.; Meng S.; Mieczkowski P.A.; Mose L.E.; Perou A.H.; Perou C.M.; Roach J.; Shi Y.; Simons J.V.; Skelly T.; Soloway M.G.; Tan D.; Veluvolu U.; Hinoue T.; Laird P.W.; Zhou W.; Bellair M.; Chang K.; Covington K.; Creighton C.J.; Dinh H.; Doddapaneni H.; Donehower L.A.; Drummond J.; Glenn R.; Hale W.; Han Y.; Hu J.; Korchina V.; Lee S.; Lewis L.; Li W.; Liu X.; Morgan M.; Morton D.; Muzny D.; Santibanez J.; Sheth M.; Shinbrot E.; Wang L.; Wang M.; Xi L.; Zhao F.; Hess J.; Appelbaum E.L.; Bailey M.; Cordes M.G.; Ding L.; Fronick C.C.; Fulton L.A.; Fulton R.S.; Kandoth C.; Mardis E.R.; McLellan M.D.; Miller C.A.; Schmidt H.K.; Wilson R.K.; Crain D.; Curley E.; Gardner J.; Lau K.; Mallery D.; Morris S.; Paulauskis J.; Penny R.; Shelton C.; Shelton T.; Sherman M.; Thompson E.; Yena P.; Bowen J.; Gastier-Foster J.M.; Gerken M.; Leraas K.M.; Lichtenberg T.M.; Ramirez N.C.; Wise L.; Zmuda E.; Corcoran N.; Costello T.; Hovens C.; Carvalho A.L.; de Carvalho A.C.; Fregnani J.H.; Longatto-Filho A.; Reis R.M.; Scapulatempo-Neto C.; Silveira H.C.S.; Vidal D.O.; Burnette A.; Eschbacher J.; Hermes B.; Noss A.; Singh R.; Anderson M.L.; Castro P.D.; Ittmann M.; Huntsman D.; Kohl B.; Le X.; Thorp R.; Andry C.; Duffy E.R.; Lyadov V.; Paklina O.; Setdikova G.; Shabunin A.; Tavobilov M.; McPherson C.; Warnick R.; Berkowitz R.; Cramer D.; Feltmate C.; Horowitz N.; Kibel A.; Muto M.; Raut C.P.; Malykh A.; Barnholtz-Sloan J.S.; Barrett W.; Devine K.; Fulop J.; Ostrom Q.T.; Shimmel K.; Wolinsky Y.; Sloan A.E.; De Rose A.; Giuliante F.; Goodman M.; Karlan B.Y.; Hagedorn C.H.; Eckman J.; Harr J.; Tucker K.; Zach L.A.; Deyarmin B.; Hu H.; Kvecher L.; Larson C.; Mural R.J.; Somiari S.; Vicha A.; Zelinka T.; Bennett J.; Iacocca M.; Rabeno B.; Swanson P.; Latour M.; Lacombe L.; Tetu B.; Bergeron A.; McGraw M.; Staugaitis S.M.; Chabot J.; Hibshoosh H.; Sepulveda A.; Su T.; Wang T.; Potapova O.; Voronina O.; Desjardins L.; Mariani O.; Roman-Roman S.; Sastre X.; Stern M.-H.; Cheng F.; Berchuck A.; Bigner D.; Lipp E.; Marks J.; McCall S.; McLendon R.; Secord A.; Sharp A.; Behera M.; Brat D.J.; Chen A.; Delman K.; Force S.; Khuri F.; Magliocca K.; Maithel S.; Olson J.J.; Owonikoko T.; Pickens A.; Ramalingam S.; Shin D.M.; Sica G.; Van Meir E.G.; Eijckenboom W.; Gillis A.; Korpershoek E.; Looijenga L.; Oosterhuis W.; Stoop H.; van Kessel K.E.; Zwarthoff E.C.; Calatozzolo C.; Cuppini L.; Cuzzubbo S.; DiMeco F.; Finocchiaro G.; Mattei L.; Perin A.; Pollo B.; Chen C.; Houck J.; Lohavanichbutr P.; Hartmann A.; Stoehr C.; Stoehr R.; Taubert H.; Wach S.; Wullich B.; Kycler W.; Murawa D.; Wiznerowicz M.; Chung K.; Edenfield W.J.; Martin J.; Baudin E.; Bubley G.; Bueno R.; De Rienzo A.; Richards W.G.; Kalkanis S.; Mikkelsen T.; Noushmehr H.; Scarpace L.; Girard N.; Aymerich M.; Campo E.; Gine E.; Guillermo A.L.; Van Bang N.; Hanh P.T.; Phu B.D.; Tang Y.; Colman H.; Evason K.; Dottino P.R.; Martignetti J.A.; Gabra H.; Juhl H.; Akeredolu T.; Stepa S.; Hoon D.; Ahn K.; Kang K.J.; Beuschlein F.; Breggia A.; Birrer M.; Bell D.; Borad M.; Bryce A.H.; Castle E.; Chandan V.; Cheville J.; Copland J.A.; Farnell M.; Flotte T.; Giama N.; Ho T.; Kendrick M.; Kocher J.-P.; Kopp K.; Moser C.; Nagorney D.; O'Brien D.; O'Neill B.P.; Patel T.; Petersen G.; Que F.; Rivera M.; Roberts L.; Smallridge R.; Smyrk T.; Stanton M.; Thompson R.H.; Torbenson M.; Yang J.D.; Zhang L.; Brimo F.; Ajani J.A.; Gonzalez A.M.A.; Behrens C.; Bondaruk J.; Broaddus R.; Czerniak B.; Esmaeli B.; Fujimoto J.; Gershenwald J.; Guo C.; Lazar A.J.; Logothetis C.; Meric-Bernstam F.; Moran C.; Ramondetta L.; Rice D.; Sood A.; Thompson T.; Troncoso P.; Tsao A.; Wistuba I.; Carter C.; Haydu L.; Hersey P.; Jakrot V.; Kakavand H.; Kefford R.; Lee K.; Long G.; Mann G.; Quinn M.; Saw R.; Scolyer R.; Shannon K.; Spillane A.; Stretch O.; Synott M.; Thompson J.; Wilmott J.; Al-Ahmadie H.; Chan T.A.; Ghossein R.; Gopalan A.; Levine D.A.; Reuter V.; Singer S.; Singh B.; Tien N.V.; Broudy T.; Mirsaidi C.; Nair P.; Drwiega P.; Miller J.; Smith J.; Zaren H.; Park J.-W.; Hung N.P.; Kebebew E.; Linehan W.M.1; Metwalli A.R.; Pacak K.; Pinto P.A.; Schiffman M.; Wentzensen N.; Worrell R.; Yang H.; Moncrieff M.; Goparaju C.; Melamed J.; Pass H.; Botnariuc N.; Caraman I.; Cernat M.; Chemencedji I.; Clipca A.; Doruc S.; Gorincioi G.; Mura S.; Pirtac M.; Stancul I.; Tcaciuc D.; Albert M.; Alexopoulou I.; Arnaout A.; Bartlett J.; Engel J.; Gilbert S.; Parfitt J.; Sekhon H.; Rassl D.M.; Rintoul R.C.; Bifulco C.; Tamakawa R.; Urba W.; Hayward N.; Timmers H.; Antenucci A.; Facciolo F.; Grazi G.; Marino M.; Merola R.; de Krijger R.; Gimenez-Roqueplo A.-P.; Piche A.; Chevalier S.; McKercher G.; Birsoy K.; Barnett G.; Brewer C.; Farver C.; Naska T.; Pennell N.A.; Raymond D.; Schilero C.; Smolenski K.; Williams F.; Morrison C.; Borgia J.A.; Liptay M.J.; Pool M.; Seder C.W.; Junker K.; Omberg L.; Dinkin M.; Manikhas G.; Alvaro D.; Bragazzi M.C.; Cardinale V.; Carpino G.; Gaudio E.; Chesla D.; Cottingham S.; Dubina M.; Moiseenko F.; Dhanasekaran R.; Becker K.-F.; Janssen K.-P.; Slotta-Huspenina J.; Abdel-Rahman M.H.; Aziz D.; Bell S.; Cebulla C.M.; Davis A.; Duell R.; Elder J.B.; Hilty J.; Kumar B.; Lang J.; Lehman N.L.; Mandt R.; Nguyen P.; Pilarski R.; Rai K.; Schoenfield L.; Senecal K.; Wakely P.; Hansen P.; Lechan R.; Powers J.; Tischler A.; Grizzle W.E.; Sexton K.C.; Kastl A.; Henderson J.; Porten S.; Waldmann J.; Fassnacht M.; Asa S.L.; Schadendorf D.; Couce M.; Graefen M.; Huland H.; Sauter G.; Schlomm T.; Simon R.; Tennstedt P.; Olabode O.; Nelson M.; Bathe O.; Carroll P.R.; Chan J.M.; Disaia P.; Glenn P.; Kelley R.K.; Landen C.N.; Phillips J.; Prados M.; Simko J.; Smith-McCune K.; VandenBerg S.; Roggin K.; Fehrenbach A.; Kendler A.; Sifri S.; Steele R.; Jimeno A.; Carey F.; Forgie I.; Mannelli M.; Carney M.; Hernandez B.; Campos B.; Herold-Mende C.; Jungk C.; Unterberg A.; von Deimling A.; Bossler A.; Galbraith J.; Jacobus L.; Knudson M.; Knutson T.; Ma D.; Milhem M.; Sigmund R.; Madan R.; Rosenthal H.G.; Adebamowo C.; Adebamowo S.N.; Boussioutas A.; Beer D.; Giordano T.; Mes-Masson A.-M.; Saad F.; Bocklage T.; Landrum L.; Mannel R.; Moore K.; Moxley K.; Postier R.; Walker J.; Zuna R.; Feldman M.; Valdivieso F.; Dhir R.; Luketich J.; Pinero E.M.M.; Quintero-Aguilo M.; Carlotti C.G.; Dos Santos J.S.; Kemp R.; Sankarankuty A.; Tirapelli D.; Catto J.; Agnew K.; Swisher E.; Creaney J.; Robinson B.; Godwin E.M.; Kendall S.; Shipman C.; Bradford C.; Carey T.; Haddad A.; Moyer J.; Peterson L.; Prince M.; Rozek L.; Wolf G.; Bowman R.; Fong K.M.; Yang I.; Korst R.; Rathmell W.K.20; Fantacone-Campbell J.L.; Hooke J.A.; Kovatich A.J.; Shriver C.D.; DiPersio J.; Drake B.; Govindan R.; Heath S.; Ley T.; Van Tine B.; Westervelt P.; Rubin M.A.; Lee J.I.; Aredes N.D.; Mariamidze A.; Spellman P.T.11
2018-04-03
Source PublicationCell Reports
ISSN22111247
Volume23Issue:1Pages:313-326.e5
Abstract

Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival. Ricketts et al. find distinctive features of each RCC subtype, providing the foundation for development of subtype-specific therapeutic and management strategies. Somatic alteration of BAP1, PBRM1, and metabolic pathways correlates with subtype-specific decreased survival, while CDKN2A alteration, DNA hypermethylation, and Th2 immune signature correlate with decreased survival within all subtypes.

KeywordCdkn2a Chromatin Remodeling Chromophobe Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Dna Hypermethylation Immune Signature Pancanatlas Papillary Renal Cell Carcinoma Tcga
DOI10.1016/j.celrep.2018.03.075
URLView the original
Language英語English
WOS IDWOS:000429092900026
Scopus ID2-s2.0-85044860979
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.National Cancer Institute
2.Centura Health
3.Leukemia Therapeutics, LLC
4.Canada's Michael Smith Genome Sciences Centre
5.Van Andel Research Institute
6.Broad Institute
7.Leidos Inc.
8.The University of North Carolina at Chapel Hill
9.Baylor College of Medicine
10.Brigham and Women's Hospital
11.Oregon Health and Science University
12.Yale University
13.Dana-Farber Cancer Institute
14.University of Texas MD Anderson Cancer Center
15.Washington University School of Medicine in St. Louis
16.University of Kansas Medical Center
17.Memorial Sloan-Kettering Cancer Center
18.Harvard Medical School
19.Mayo Clinic Scottsdale-Phoenix, Arizona
20.Vanderbilt University School of Medicine
Recommended Citation
GB/T 7714		 Ricketts C.J.,De Cubas A.A.,Fan H.,et al. The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma[J]. Cell Reports, 2018, 23(1), 313-326.e5.
APA Ricketts C.J.., De Cubas A.A.., Fan H.., Smith C.C.., Lang M.., Reznik E.., Bowlby R.., Gibb E.A.., Akbani R.., Beroukhim R.., Bottaro D.P.., Choueiri T.K.., Gibbs R.A.., Godwin A.K.., Haake S.., Hakimi A.A.., Henske E.P.., Hsieh J.J.., Ho T.H.., ...& Spellman P.T. (2018). The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Reports, 23(1), 313-326.e5.
MLA Ricketts C.J.,et al."The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma".Cell Reports 23.1(2018):313-326.e5.
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