| Residential College | false |
| Status | 已發表Published |
| Noninvasive assessment of liver function reserve with fluorescent dosimetry of indocyanine green | |
Wu, Pei Chun1,2,3; Guo, Lun Zhang2; Yu, Shan1,4 ; Zeng, Ning5,6; Liu, Yu Cheng1; Yu, Jia1; Zhang, Zhiming1; Lu, Ke1; Sun, Liangyu1; Wang, Chunfei1; Chang, Yu Han2,3; Lu, Yin Lin1,3; Shen, Yu Fang7,8; Tai, Sheng9; Chuang, Yueh Hsun10; Annie Ho, Ja An11; Huang, Kai Wen12; Wu, Yao Ming13; Liu, Tzu Ming1 
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| 2022-04-01 | |
| Source Publication | Biomedical Optics Express
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| ISSN | 2156-7085 |
| Volume | 13Issue:4Pages:1995-2005 |
| Abstract | Using in vivo multiphoton fluorescent dosimetry, we demonstrate that the clearance dynamics of Indocyanine Green (ICG) in the blood can quickly reveal liver function reserve. In normal rats, the ICG retention rate was below 10% at the 15-minute post-administration; While in the rat with severe hepatocellular carcinoma (HCC), the 15-minute retention rate is over 40% due to poor liver metabolism. With a 785 nm CW laser, the fluorescence dosimeter can evaluate the liver function reserve at a 1/10 clinical dosage of ICG without any blood sampling. In the future, this low-dosage ICG 15-minute retention dosimetry can be applied for the preoperative assessment of hepatectomy or timely perioperative examination. |
| DOI | 10.1364/BOE.446749 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000796716700002 |
| Publisher | OPTICAL SOC AMER2010 MASSACHUSETTS AVE NW, WASHINGTON, DC 20036 |
| Scopus ID | 2-s2.0-85126987923 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Translational Medicine Faculty of Health Sciences |
| Corresponding Author | Liu, Tzu Ming |
| Affiliation | 1.Institute of Translational Medicine, Faculty of Health Sciences, Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macao 2.Department of Biomedical Engineering, National Taiwan University, Taipei, 10617, Taiwan 3.Molecular Imaging Center, National Taiwan University, Taipei, 10617, Taiwan 4.Department of Pathology, The Secondary Affiliated Hospital, Harbin Medical University, Harbin, 150080, China 5.First Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China 6.Guangdong Provincial Clinical and Engineering Technology Center of Digital Medicine, Guangzhou, 510280, China 7.3D Printing Medical Research Institute, Asia University, Taichung, 41354, Taiwan 8.Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 41354, Taiwan 9.Department of Hepatopancreatobiliary Surgery, The Secondary Affiliated Hospital, Harbin Medical University, Harbin, 150080, China 10.Department of Anesthesiology, National Taiwan University Hospital, Taipei, 10002, Taiwan 11.Bioanalytical Chemistry and Nanobiomedicine Laboratory, Department of Biochemical Science & Technology, National Taiwan University, Taipei, 10617, Taiwan 12.Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, 10002, Taiwan 13.Department of Surgery, National Taiwan University Hospital, College of Medicine, Taipei, 10002, Taiwan |
| First Author Affilication | Faculty of Health Sciences |
| Corresponding Author Affilication | Faculty of Health Sciences |
| Recommended Citation GB/T 7714 | Wu, Pei Chun,Guo, Lun Zhang,Yu, Shan,et al. Noninvasive assessment of liver function reserve with fluorescent dosimetry of indocyanine green[J]. Biomedical Optics Express, 2022, 13(4), 1995-2005. |
| APA | Wu, Pei Chun., Guo, Lun Zhang., Yu, Shan., Zeng, Ning., Liu, Yu Cheng., Yu, Jia., Zhang, Zhiming., Lu, Ke., Sun, Liangyu., Wang, Chunfei., Chang, Yu Han., Lu, Yin Lin., Shen, Yu Fang., Tai, Sheng., Chuang, Yueh Hsun., Annie Ho, Ja An., Huang, Kai Wen., Wu, Yao Ming., & Liu, Tzu Ming (2022). Noninvasive assessment of liver function reserve with fluorescent dosimetry of indocyanine green. Biomedical Optics Express, 13(4), 1995-2005. |
| MLA | Wu, Pei Chun,et al."Noninvasive assessment of liver function reserve with fluorescent dosimetry of indocyanine green".Biomedical Optics Express 13.4(2022):1995-2005. |
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