Exploration of dysregulated lncRNA-mRNA network from the RNA-seq data of rats induced by three different synthetic cytotoxic compounds

doi:10.1109/BIBM.2018.8621456

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	Exploration of dysregulated lncRNA-mRNA network from the RNA-seq data of rats induced by three different synthetic cytotoxic compounds
	Leng, Dongliang; Huang, Chen; Lei, Johnny; Sun, Shixue; Xd, Zhang
	2019-01-21
Conference Name	2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
Source Publication	Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
Pages	2527-2534
Conference Date	2018/12/03-2018/12/06
Conference Place	Madrid, Spain
Abstract	Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) play important roles in initiation and development of human diseases. However, the mechanism of the targets regulated by lncRNA remains unclear. In this study, we performed a multi-step computational analysis to construct dysregulated lncRNA-mRNA networks for the rats' RNAseq data induced by three different synthetic cytotoxic compounds (CARBON TETRACHLORIDE, CHLOROFORM, THIOACETAMIDE). We systematically integrated lncRNA and mRNA expression profiles and lncRNA-mRNA regulatory interactions. The constructed interaction network exhibited biological network characteristics, and functional analysis demonstrated that the networks were specific for inducing synthetic compounds. Additionally, we identified some lncRNA-mRNA modules. This study will provide us new insight into lncRNA-mRNA regulatory mechanisms involved in rats induced by three different synthetic cytotoxic compounds and will facilitate the discovery of candidate diagnostic and prognosis biomarkers for related diseases.
Keyword	Cytotoxin Lncrnas Network Rna Sequencing
DOI	10.1109/BIBM.2018.8621456
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85062540613
Fulltext Access	View Full-Text via DOI View Full-Text via Scopus
Citation statistics
Document Type	Conference paper
Collection	Faculty of Health Sciences
Co-First Author	Leng, Dongliang
Corresponding Author	Xd, Zhang
Affiliation	Faculty of Health Sciences, University of Macau, Taipa, Macao
First Author Affilication	Faculty of Health Sciences
Corresponding Author Affilication	Faculty of Health Sciences
Recommended Citation GB/T 7714	Leng, Dongliang,Huang, Chen,Lei, Johnny,et al. Exploration of dysregulated lncRNA-mRNA network from the RNA-seq data of rats induced by three different synthetic cytotoxic compounds[C], 2019, 2527-2534.
APA	Leng, Dongliang., Huang, Chen., Lei, Johnny., Sun, Shixue., & Xd, Zhang (2019). Exploration of dysregulated lncRNA-mRNA network from the RNA-seq data of rats induced by three different synthetic cytotoxic compounds. Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, 2527-2534.

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