The primary goal of this study was to examine job insecurity as a work stressor predicting psychological distress (i.e. depression, anxiety, and stress) among casino employees in Macao, China. The study was also the first one to test whether occupational future time perspective mediated the above relations. We recruited 1014 participants, who voluntarily took part in an anonymous survey in October 2016. Results suggested that job insecurity was positively related to psychological distress (i.e. depression, anxiety and stress). In line with our hypothesis, we also found that occupational future time perspective significantly mediated the association between job insecurity and psychological distress. The findings suggest that, in psychological health promotion campaigns among casino employees, job insecurity is a key factor to be addressed via organizational policies and activities.