Objective：To investigate the inhibitory effects of total flavonoids from the leaves of Carya cathayensis sarg. and their four monomer compounds, namely pinostrobin chalcone, pinocembrin, chrysin and wogonin on angiotensinⅡ-induced proliferation and migration in rat vascular smooth muscle cells (VSMC). Methods：VSMC were primary cultured by tissue sticking method. VSMC proliferation was induced by 100 nmol•L-1 AngⅡ for 12 h after treatment of serum starvation at the initial density of 2.0×104/mL. VSMC migration was induced by 100 nmol•L-1 AngⅡ for 12 h at the initial density of 6.0×104/mL. Both of them were treated with 12.5—62.5 μg•mL-1 total flavonoids, 10—50 μg•mL-1 pinostrobin chalcone, pinocembrin, chrysin and wogonin for 12 h. Cell proliferation was measured by direct counting the cells and cell migration was determined using the wound healing assay, respectively. Results：12.5 μg•mL-1 total flavonoids significantly inhibited AngⅡ-induced VSMC proliferation in a does dependent manner while 50 μg•mL-1pinostrobin chalcone, chrysin and wogonin slightly inhibited AngⅡ-induced VSMC proliferation. 12.5 μg•mL-1 total flavonoids, 10 μg•mL-1 pinostrobin chalcone, pinocembrin, chrysin and wogonin significantly inhibited AngⅡ-induced VSMC migration in a does dependent manner. Among them, the total flavonoids, chrysin and wogonin showed a higher inhibitory effect compared with those of pinocembrin and pinostrobin chalcone. Conclusion：The total flavonoids from the leaves of Carya cathayensis sarg. effectively inhibited AngⅡ-induced VSMC proliferation and migration, while their four monomer compounds present better suppressive activities on AngⅡ-induced migration than those of proliferation in VSMC.