Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3

doi:10.1074/jbc.M115.679852

UM > Faculty of Health Sciences

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	Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3
	Ahmed M.; Cheng M.; Zhao Q.; Goldgur Y.; Cheal S.M.; Guo H.-F.; Larson S.M.; Cheung N.-K.V.
	2015-12-11
Source Publication	Journal of Biological Chemistry
ISSN	1083351X 00219258
Volume	290 Issue:50 Pages:30018-30029
Abstract	Background: B7-H3 is an immune inhibitory ligand and an antigen on many solid tumors. Results: Antibody 8H9 was humanized and affinity-matured, and its epitope was mapped to the FG loop of B7-H3. Conclusion: hu8H9 antibodies had potent antitumor activity and may modulate immune inhibitory properties of B7-H3. Significance: Antibodies were developed to target solid tumors and affect immune checkpoint blockade.
DOI	10.1074/jbc.M115.679852
URL	View the original
Indexed By	SCIE
WOS Research Area	Biochemistry & Molecular Biology
WOS Subject	Biochemistry & Molecular Biology
WOS ID	WOS:000366614700033
Scopus ID	2-s2.0-84949639635
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Faculty of Health Sciences
Affiliation	Memorial Sloan-Kettering Cancer Center
Recommended Citation GB/T 7714	Ahmed M.,Cheng M.,Zhao Q.,et al. Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3[J]. Journal of Biological Chemistry, 2015, 290(50), 30018-30029.
APA	Ahmed M.., Cheng M.., Zhao Q.., Goldgur Y.., Cheal S.M.., Guo H.-F.., Larson S.M.., & Cheung N.-K.V. (2015). Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3. Journal of Biological Chemistry, 290(50), 30018-30029.
MLA	Ahmed M.,et al."Humanized affinity-matured monoclonal antibody 8H9 has potent antitumor activity and binds to FG loop of tumor antigen B7-H3".Journal of Biological Chemistry 290.50(2015):30018-30029.

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