| Residential College | false |
| Status | 已發表Published |
| Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells | |
Meng Y.1,2; Ren Z.1 ; Xu F.1; Zhou X.1; Song C.1; Wang V.Y.-F.2,3 ; Liu W.1; Lu L.4; Thomson J.A.5; Chen G.1,2
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| 2018-12-11 | |
| Source Publication | Stem Cell Reports
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| ISSN | 2213-6711 |
| Volume | 11Issue:6Pages:1347-1356 |
| Abstract | In this report, Guokai Chen and colleagues show that nicotinamide is a kinase inhibitor with multiple targets. Nicotinamide improves human pluripotent stem cell (hPSC) survival as a ROCK inhibitor, and it also induces hPSC differentiation as a casein kinase 1 inhibitor. This discovery highlights nicotinamide's regulatory function beyond its common roles in metabolism, PARP, and sirtuin pathways. |
| Keyword | Cell Differentiation Cell Survival Human Pluripotent Stem Cell Kinase Inhibitor Nicotinamide |
| DOI | 10.1016/j.stemcr.2018.10.023 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Cell Biology |
| WOS Subject | Cell & Tissue Engineering ; Cell Biology |
| WOS ID | WOS:000452898300008 |
| Publisher | CELL PRESS |
| Scopus ID | 2-s2.0-85058591104 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Faculty of Health Sciences |
| Corresponding Author | Chen G. |
| Affiliation | 1.Centre of Reproduction, Development & Aging, Faculty of Health Sciences, University of Macau, Taipa, Macau, China 2.Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, China 3.Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau, China 4.Bioimaging and Stem Cell Core Facility, Faculty of Health Sciences, University of Macau, Taipa, Macau, China 5.Center of Interventional Radiology, Zhuhai Precision Medical Center, Zhuhai People's Hospital, Jinan University, Zhuhai, Guangdong 519000, China 6.Regenerative Biology, Morgridge Institute for Research, Madison, WI 53715, USA 7.Department of Cell & Regenerative Biology, University of Wisconsin–Madison, Madison, WI 53706, USA |
| First Author Affilication | Faculty of Health Sciences |
| Corresponding Author Affilication | Faculty of Health Sciences |
| Recommended Citation GB/T 7714 | Meng Y.,Ren Z.,Xu F.,et al. Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells[J]. Stem Cell Reports, 2018, 11(6), 1347-1356. |
| APA | Meng Y.., Ren Z.., Xu F.., Zhou X.., Song C.., Wang V.Y.-F.., Liu W.., Lu L.., Thomson J.A.., & Chen G. (2018). Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells. Stem Cell Reports, 11(6), 1347-1356. |
| MLA | Meng Y.,et al."Nicotinamide Promotes Cell Survival and Differentiation as Kinase Inhibitor in Human Pluripotent Stem Cells".Stem Cell Reports 11.6(2018):1347-1356. |
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