A functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression

doi:10.1007/s12031-008-9083-5

UM > Faculty of Health Sciences

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Status	已發表Published
	A functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression
	Lee L.T.O.; Lam I.P.Y.; Chow B.K.C.
	2008-11-01
Source Publication	Journal of Molecular Neuroscience
ISSN	08958696
Volume	36 Issue:1-3 Pages:125-131
Abstract	Secretin is a peptide hormone playing multiple functions in the brain-gut axis. In this report, we investigated, by promoter analysis, the potential function of the variable of tandem repeats (VNTR), located at the 5′ upstream region of the human secretin gene, and we demonstrated for the first time that this VNTR could downregulate transcription of the human secretin gene in a promoter-specific manner. The efficiency of VNTR in silencing the promoter was found to be directly related the number of repetitive units residing within. We also showed the deoxyribonucleic acid sequence as well as the length polymorphism of the VNTR of 76 Chinese individuals. These results collectively suggest that VNTR could potentially be a functional regulator to control the expression of the human secretin gene in different individuals. © 2008 Humana Press.
Keyword	Gene Expression Secretin Variable Number Of Tandem Repeats
DOI	10.1007/s12031-008-9083-5
URL	View the original
Language	英語English
WOS ID	WOS:000261180200016
Scopus ID	2-s2.0-58149089287
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Faculty of Health Sciences
Affiliation	The University of Hong Kong
Recommended Citation GB/T 7714	Lee L.T.O.,Lam I.P.Y.,Chow B.K.C.. A functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression[J]. Journal of Molecular Neuroscience, 2008, 36(1-3), 125-131.
APA	Lee L.T.O.., Lam I.P.Y.., & Chow B.K.C. (2008). A functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression. Journal of Molecular Neuroscience, 36(1-3), 125-131.
MLA	Lee L.T.O.,et al."A functional variable number of tandem repeats is located at the 5′ flanking region of the human secretin gene plays a downregulatory role in expression".Journal of Molecular Neuroscience 36.1-3(2008):125-131.

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