Discovery of three new monoterpenoid indole alkaloids from the leaves of gardneria multiflora and their vasorelaxant and ache inhibitory activities

doi:10.3390/molecules26237191

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	Discovery of three new monoterpenoid indole alkaloids from the leaves of gardneria multiflora and their vasorelaxant and ache inhibitory activities
	Zhang, Sheng Yuan 1; Li, Zi Wei 2; Xu, Jie 2; Chen, Qiu Ling 2; Song, Min 3; Zhang, Qing Wen3,4
	2021-12-01
Source Publication	Molecules
Volume	26 Issue:23
Abstract	Three novel monoterpenoid indole alkaloids gardflorine A (1), gardflorine B (2), and gardflorine C (3) were isolated from the leaves of Gardneria multiflora. Their structures, including absolute configurations, were established on the basis of spectroscopic methods (MS, UV, IR, 1D and 2D NMR) and circular dichroism experiments. All the compounds were evaluated for their vasorelaxant and acetylcholinesterase (AChE) inhibitory activities. Compound 1 exhibited potent vasorelaxant activity, with an EC value of 8.7 µM, and compounds 2 and 3 showed moderate acetylcholinesterase (AChE) inhibitory activities, with IC values of 26.8 and 29.2 µM, respectively.
Keyword	Ache Inhibitory Activity Gardneria Multiflora Monoterpenoid Indole Alkaloid Vasorelaxant Activity
DOI	10.3390/molecules26237191
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Biochemistry & Molecular Biology ; Chemistry
WOS Subject	Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS ID	WOS:000734504800001
Scopus ID	2-s2.0-85120628657
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Faculty of Health Sciences Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) DEPARTMENT OF PHARMACEUTICAL SCIENCES
Corresponding Author	Zhang, Qing Wen
Affiliation	1.Guangdong Provincial Key Laboratory of Conservation and Precision Utilization of Characteristic Agricultural Resources in Mountainous Areas, Jiaying University, Meizhou, 514015, China 2.NMPA Key Laboratory for Quality Evaluation of TCM, Guangdong Provincial Engineering Research Center for Modernization of TCM, Jinan University, Guangzhou, 510632, China 3.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, 999078, Macao 4.Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, 999078, Macao
Corresponding Author Affilication	Institute of Chinese Medical Sciences; Faculty of Health Sciences
Recommended Citation GB/T 7714	Zhang, Sheng Yuan,Li, Zi Wei,Xu, Jie,et al. Discovery of three new monoterpenoid indole alkaloids from the leaves of gardneria multiflora and their vasorelaxant and ache inhibitory activities[J]. Molecules, 2021, 26(23).
APA	Zhang, Sheng Yuan., Li, Zi Wei., Xu, Jie., Chen, Qiu Ling., Song, Min., & Zhang, Qing Wen (2021). Discovery of three new monoterpenoid indole alkaloids from the leaves of gardneria multiflora and their vasorelaxant and ache inhibitory activities. Molecules, 26(23).
MLA	Zhang, Sheng Yuan,et al."Discovery of three new monoterpenoid indole alkaloids from the leaves of gardneria multiflora and their vasorelaxant and ache inhibitory activities".Molecules 26.23(2021).

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