Network modeling is one of the most popular and powerful tools for studying complex systems because it enables the thorough investigation of the multiple types of complex systems, both on local and global level. In this study, we employed GEDEVO,a network alignment dynamic algorithm, to measure the similarities of the PPI networks between different organisms. The coming comparative analysis of the evolution conservation  between orthologous molecule level and PPI network revealed that the biomolecules are more conservative than molecular interactions in evolution. Our results offer insights of molecular basis and mechanisms for evolutionary studies.