| Residential College | false |
| Status | 已發表Published |
| Estimating the “First in human” dose – a revisit with particular emphasis on oncology drugs | |
Kin Tam 
| |
| 2013 | |
| Source Publication | ADMET & DMPK
 |
| ISSN | 1848-7718 |
| Volume | 1Issue:4Pages:63-75 |
| Abstract | The initial dose selection is one of the important steps for any investigative new drug (IND) entering the first clinical study in humans. In this mini review, we will discuss the no observed adverse effect level (NOAEL) and the minimum anticipated biological effect level (MABEL) approaches for the estimation of the first in human (FIH) dose. Particular attention will be placed on the development of the FIH dose for oncology drugs |
| Keyword | Initial Dose Starting Dose Clinical Trial Noael Mabel Cytotoxic Anticancer Combination Therapy Study |
| DOI | 10.5599/admet.1.4.10 |
| Indexed By | ESCI |
| Language | 英語English |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal ; Pharmacology & Pharmacy |
| WOS ID | WOS:000447330700003 |
| Publisher | IAPC PUBLISHING, S ALICA 4, ZAGREB HR-10000, CROATIA |
| Scopus ID | 2-s2.0-85018918695 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Faculty of Health Sciences |
| Corresponding Author | Kin Tam |
| Affiliation | Faculty of Health Science, University of Macau, Macau, China |
| First Author Affilication | University of Macau |
| Corresponding Author Affilication | University of Macau |
| Recommended Citation GB/T 7714 | Kin Tam. Estimating the “First in human” dose – a revisit with particular emphasis on oncology drugs[J]. ADMET & DMPK, 2013, 1(4), 63-75. |
| APA | Kin Tam.(2013). Estimating the “First in human” dose – a revisit with particular emphasis on oncology drugs. ADMET & DMPK, 1(4), 63-75. |
| MLA | Kin Tam."Estimating the “First in human” dose – a revisit with particular emphasis on oncology drugs".ADMET & DMPK 1.4(2013):63-75. |
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