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Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs
Matěj Velický1; Andrew N.J. Rodgers1; Robert A.W. Dryfe1; Kin Tam2
2014
Source PublicationADMET & DMPK
ISSN1848-7718
Volume2Issue:3Pages:143-156
Abstract

In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusion coefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies.

KeywordCyclic Voltammetry Partition Coefficient Diffusion Coefficient Permeability Ities
DOI10.5599/admet.2.3.22
Language英語English
WOS IDWOS:000447332100001
Scopus ID2-s2.0-84959916162
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorMatěj Velický
Affiliation1.School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
2.Faculty of Health Science, University of Macau, Macau, China
Recommended Citation
GB/T 7714
Matěj Velický,Andrew N.J. Rodgers,Robert A.W. Dryfe,et al. Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs[J]. ADMET & DMPK, 2014, 2(3), 143-156.
APA Matěj Velický., Andrew N.J. Rodgers., Robert A.W. Dryfe., & Kin Tam (2014). Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs. ADMET & DMPK, 2(3), 143-156.
MLA Matěj Velický,et al."Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs".ADMET & DMPK 2.3(2014):143-156.
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