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PH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy
Lei Xing1; Jin-Yuan Lyu1; Yue Yang1; Peng-Fei Cui1; Liu-Qing Gu1; Jian-Bin Qiao1; Yu-Jing He1; Tian-Qi Zhang1; Minjie Sun1; Jin-Jian Lu2; Xiaojun Xu1; Yu Liu1; Hu-Lin Jiang1
2017
Source PublicationChemical Communications
ISSN1364548X 13597345
Volume53Issue:62Pages:8790-8793
Abstract

We have developed mitochondria-targeted self-assembled nanoparticles (NPs) based on amphiphilic triphenylphosphine-quercetin (TPP-Que) conjugates, which were further modified by poly(ethylene glycol) via a pH-responsive coordination bond to form TQ-PEG NPs. And it is revealed that the TQ-PEG NPs were more effective therapeutic agents compared with Que in vitro and in vivo.

DOI10.1039/c7cc04058j
URLView the original
Indexed BySCIE
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000406669000039
Scopus ID2-s2.0-85026843433
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Citation statistics
Document TypeJournal article
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Institute of Chinese Medical Sciences
THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Corresponding AuthorXiaojun Xu; Yu Liu; Hu-Lin Jiang
Affiliation1.China Pharmaceutical University
2.Universidade de Macau
Recommended Citation
GB/T 7714		 Lei Xing,Jin-Yuan Lyu,Yue Yang,et al. PH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy[J]. Chemical Communications, 2017, 53(62), 8790-8793.
APA Lei Xing., Jin-Yuan Lyu., Yue Yang., Peng-Fei Cui., Liu-Qing Gu., Jian-Bin Qiao., Yu-Jing He., Tian-Qi Zhang., Minjie Sun., Jin-Jian Lu., Xiaojun Xu., Yu Liu., & Hu-Lin Jiang (2017). PH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy. Chemical Communications, 53(62), 8790-8793.
MLA Lei Xing,et al."PH-Responsive de-PEGylated nanoparticles based on triphenylphosphine-quercetin self-assemblies for mitochondria-targeted cancer therapy".Chemical Communications 53.62(2017):8790-8793.
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