Comparison of the cytotoxicity of five constituents from Pteris semipinnata L. in vitro and the analysis of their structure-activity relationships

UM > Institute of Chinese Medical Sciences

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	Comparison of the cytotoxicity of five constituents from Pteris semipinnata L. in vitro and the analysis of their structure-activity relationships
	Li J.; Liang N.; Mo L.; Zhang X.; He C.
	1998-09-01
Source Publication	Yaoxue Xuebao
ISSN	05134870
Volume	33 Issue:9 Pages:641-644
Abstract	The antitumor constituents were isolated from Pteris semipinnata L. (PsL), a Chinese traditional herb, and screened using tetrazolium salt (MTT) method. Their cytotoxic effects in vitro on several human tumor cell lines were studied. Compounds 5F, 6F, A and the ethanolic extract of PsL (PSE) were shown to have strong cytotoxicity against five cell lines: human liver adenocarcinoma cell line (HePG II), human lung adenocarcinom a cell line (SPC-A-1), human gastric adenocarcinoma cell line (MGC-803), human nasopharyngeal carcinoma cells in low differentiation (CNE-2Z) and human liver adenocarcinoma cell line (BEL-7402) in different degrees in a dose-dependent manner; compound 6F was the most active one, whose IC after 72 h treatment for the above five cell lines were 0.343 ± 0.003, 0.115 + 0.022, 0.590 ± 0.032, 0.328 ± 0.066 and 0.221 ± 0.058 μg·ml, respectively. Compounds A and 5F were less active; no cytotoxicity of compounds 4F and B were detected on the five cell lines. Analysis of the relationship between structure and activity revealed that the antitumor activity portion in the structure is the α, β-methylene cyclopentanone moiety, and the site and number of the hydroxy groups affect the cytotoxicity of these agents significantly.
Keyword	Cytotoxicity Diterpenoids Pteris semipinnata L. Structure-activity relationship
URL	View the original
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Affiliation	Guangdong Medical University
Recommended Citation GB/T 7714	Li J.,Liang N.,Mo L.,et al. Comparison of the cytotoxicity of five constituents from Pteris semipinnata L. in vitro and the analysis of their structure-activity relationships[J]. Yaoxue Xuebao, 1998, 33(9), 641-644.
APA	Li J.., Liang N.., Mo L.., Zhang X.., & He C. (1998). Comparison of the cytotoxicity of five constituents from Pteris semipinnata L. in vitro and the analysis of their structure-activity relationships. Yaoxue Xuebao, 33(9), 641-644.
MLA	Li J.,et al."Comparison of the cytotoxicity of five constituents from Pteris semipinnata L. in vitro and the analysis of their structure-activity relationships".Yaoxue Xuebao 33.9(1998):641-644.

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