Effect of active compounds isolated from Pteris semipinnata L on DNA topoisomerases and tyrosine protein kinase and expression of c-myc in lung adenocarcinoma cells

doi:10.1007/s11670-001-0025-9

Residential College	false
Status	已發表Published
	Effect of active compounds isolated from Pteris semipinnata L on DNA topoisomerases and tyrosine protein kinase and expression of c-myc in lung adenocarcinoma cells
	Li J.-H.; Liang N.-C.; Mo L.-E.; Zhang X.; He C.-W.
	2001
Source Publication	Chinese Journal of Cancer Research
ISSN	10009604
Volume	13 Issue:2 Pages:105-109
Abstract	Objective: To study the effect of active compound 6F and A from Pteris semipinnata L.(PsL) on the activities of DNA topoisomerase (TOPO) I and II, activities of cytosolic and membrane TPK, and expression of oncogene c-myc in lung adenocarcinoma cells. Methods: The effect of compound 6F and A on activities of cytosolic and membrane TPK was measured by scintillation counting; the effect of compound A on expression of oncogene c-myc was determined by flow cytometry indirect fluorimetry. Results: compound 6F and A could inhibit the activities of TOPO I, and they strongly inhibited the TOPO II in 0.01 mg/L and 10.0 mg/L respectively. Compound A slightly inhibited the activities of membrane TPK, but not the cytosolic one. Compound A could inhibit the expression of oncogene c-myc. Conclusion: Topoisomerases are target of compound 6F and A. Compound A could slightly inhibit the activities of TPK, and showed an inhibitory effect on the expression of oncogene c-myc.
Keyword	C-myc Dna Topoisomerase Pteris Semipinnata L. Tyrosine Protein Kinase
DOI	10.1007/s11670-001-0025-9
URL	View the original
Language	英語English
Scopus ID	2-s2.0-0034930710
Fulltext Access	View Full-Text via DOI View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	Guangdong Medical University
Recommended Citation GB/T 7714	Li J.-H.,Liang N.-C.,Mo L.-E.,et al. Effect of active compounds isolated from Pteris semipinnata L on DNA topoisomerases and tyrosine protein kinase and expression of c-myc in lung adenocarcinoma cells[J]. Chinese Journal of Cancer Research, 2001, 13(2), 105-109.
APA	Li J.-H.., Liang N.-C.., Mo L.-E.., Zhang X.., & He C.-W. (2001). Effect of active compounds isolated from Pteris semipinnata L on DNA topoisomerases and tyrosine protein kinase and expression of c-myc in lung adenocarcinoma cells. Chinese Journal of Cancer Research, 13(2), 105-109.
MLA	Li J.-H.,et al."Effect of active compounds isolated from Pteris semipinnata L on DNA topoisomerases and tyrosine protein kinase and expression of c-myc in lung adenocarcinoma cells".Chinese Journal of Cancer Research 13.2(2001):105-109.

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