| Residential College | false |
| Status | 已發表Published |
| Effects of arsenic trioxide induced the apoptosis of JEC human endometrial adenocarcinoma cell line in vitro | |
| Xun K.-L.; Zhang X.-J.; Long X.-Z.; Chen X.-P.; Tan X.-S. | |
| 2006 | |
| Source Publication | Chinese Journal of Endemiology
 |
| ISSN | 10004955 |
| Volume | 25Issue:1Pages:16-18 |
| Abstract | Objective: To investigate the apoptosis effect of arsenic trioxide on the JEC human endometrium adenocarcinoma cell line in vitro. Methods: The JEC cells was cultured in vitro. The morphological changes of the JEC cells were observed by transmission electron microscope. The content of DNA,the changes of cell cycle and the apoptosis of the cells were analyzed by flow cytometry. Results: (1) When the cells were treated with ASO at a concentration of 4.0 μmol/L lasting for 72 h, karyopyknosis and karyorrhexis were observed under transmission electron microscope; the concentration increasing to 8.0 and 16.0 μmol/L lasting for 48 h,karyorrhexis appeared under transmission electron microscope; (2) When the concentration of ASO was lower than 2.0 μmol/L, the cells in G/G and S phase was significantly decreased, the cells in G/M phase was increased; when the concentration was 2.0 - 4.0 μmol/L,a typical hypodiploid peak before G phase was shown,when the concentration was 8.0 - 16.0 μmol/L,the cells were mainly necrotized. Conclusions: ASO can induce the apoptosis of JEC human endometrium adenocarcinoma cell line. |
| Keyword | Apoptosis Arsenic trioxide Cells, cultured Endometrial neoplasms JEC cell line |
| URL | View the original |
| Language | 英語English |
| Fulltext Access | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | Zunyi Medical College |
| Recommended Citation GB/T 7714 | Xun K.-L.,Zhang X.-J.,Long X.-Z.,et al. Effects of arsenic trioxide induced the apoptosis of JEC human endometrial adenocarcinoma cell line in vitro[J]. Chinese Journal of Endemiology, 2006, 25(1), 16-18. |
| APA | Xun K.-L.., Zhang X.-J.., Long X.-Z.., Chen X.-P.., & Tan X.-S. (2006). Effects of arsenic trioxide induced the apoptosis of JEC human endometrial adenocarcinoma cell line in vitro. Chinese Journal of Endemiology, 25(1), 16-18. |
| MLA | Xun K.-L.,et al."Effects of arsenic trioxide induced the apoptosis of JEC human endometrial adenocarcinoma cell line in vitro".Chinese Journal of Endemiology 25.1(2006):16-18. |
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