Residential College | false |
Status | 已發表Published |
Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis | |
Huang, Zhilin1; Liu, Qiang2; Peng, Yu2; Dai, Jiaying3; Xie, Youna1; Chen, Weineng1; Long, Simei1; Pei, Zhong1; Su, Huanxing2; Yao, Xiaoli1 | |
2018-04-24 | |
Source Publication | FRONTIERS IN NEUROLOGY |
ISSN | 1664-2295 |
Volume | 9 |
Abstract | Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by interactions between environmental factors and genetic susceptibility. Circadian rhythm dysfunction (CRD) is a significant contributor to neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. However, whether CRD contributes to the progression of ALS remains little known. We performed behavioral and physiological tests on SOD1G93A ALS model mice with and without artificially induced CRD, and on wild -type controls; we also analyzed spinal cord samples histologically for differences between groups. We found that CRD accelerated the disease onset and progression of ALS in model mice, as demonstrated by aggravated functional deficits and weight loss, as well as increased motor neuron loss, activated gliosis, and nuclear factor KB -mediated inflammation in the spinal cord. We also found an increasing abundance of enteric cyanobacteria in the ALS model mice shortly after disease onset that was further enhanced by CRD. Our study provides initial evidence on the CRD as a risk factor for ALS, and intestinal cyanobacteria may be involved. |
Keyword | Circadian Rhythm Dysfunction Amyotrophic Lateral Sclerosis Inflammation Nf-kb Cyanobacteria |
DOI | 10.3389/fneur.2018.00218 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Neurosciences & Neurology |
WOS Subject | Clinical Neurology ; Neurosciences |
WOS ID | WOS:000430747900001 |
Publisher | FRONTIERS MEDIA SA |
The Source to Article | WOS |
Scopus ID | 2-s2.0-85046675351 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences |
Corresponding Author | Su, Huanxing; Yao, Xiaoli |
Affiliation | 1.Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, Guangdong Key Clinical Laboratory for Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China 3.Comprehensive Department, Sun Yat-sen Memorial Hospital affiliated to Sun Yat-sen University, Guangzhou, China |
Corresponding Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Huang, Zhilin,Liu, Qiang,Peng, Yu,et al. Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis[J]. FRONTIERS IN NEUROLOGY, 2018, 9. |
APA | Huang, Zhilin., Liu, Qiang., Peng, Yu., Dai, Jiaying., Xie, Youna., Chen, Weineng., Long, Simei., Pei, Zhong., Su, Huanxing., & Yao, Xiaoli (2018). Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis. FRONTIERS IN NEUROLOGY, 9. |
MLA | Huang, Zhilin,et al."Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis".FRONTIERS IN NEUROLOGY 9(2018). |
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