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Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis
Huang, Zhilin1; Liu, Qiang2; Peng, Yu2; Dai, Jiaying3; Xie, Youna1; Chen, Weineng1; Long, Simei1; Pei, Zhong1; Su, Huanxing2; Yao, Xiaoli1
2018-04-24
Source PublicationFRONTIERS IN NEUROLOGY
ISSN1664-2295
Volume9
Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by interactions between environmental factors and genetic susceptibility. Circadian rhythm dysfunction (CRD) is a significant contributor to neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. However, whether CRD contributes to the progression of ALS remains little known. We performed behavioral and physiological tests on SOD1G93A ALS model mice with and without artificially induced CRD, and on wild -type controls; we also analyzed spinal cord samples histologically for differences between groups. We found that CRD accelerated the disease onset and progression of ALS in model mice, as demonstrated by aggravated functional deficits and weight loss, as well as increased motor neuron loss, activated gliosis, and nuclear factor KB -mediated inflammation in the spinal cord. We also found an increasing abundance of enteric cyanobacteria in the ALS model mice shortly after disease onset that was further enhanced by CRD. Our study provides initial evidence on the CRD as a risk factor for ALS, and intestinal cyanobacteria may be involved.

KeywordCircadian Rhythm Dysfunction Amyotrophic Lateral Sclerosis Inflammation Nf-kb Cyanobacteria
DOI10.3389/fneur.2018.00218
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology ; Neurosciences
WOS IDWOS:000430747900001
PublisherFRONTIERS MEDIA SA
The Source to ArticleWOS
Scopus ID2-s2.0-85046675351
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorSu, Huanxing; Yao, Xiaoli
Affiliation1.Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, Guangdong Key Clinical Laboratory for Diagnosis and Treatment of Major Neurological Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.Comprehensive Department, Sun Yat-sen Memorial Hospital affiliated to Sun Yat-sen University, Guangzhou, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huang, Zhilin,Liu, Qiang,Peng, Yu,et al. Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis[J]. FRONTIERS IN NEUROLOGY, 2018, 9.
APA Huang, Zhilin., Liu, Qiang., Peng, Yu., Dai, Jiaying., Xie, Youna., Chen, Weineng., Long, Simei., Pei, Zhong., Su, Huanxing., & Yao, Xiaoli (2018). Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis. FRONTIERS IN NEUROLOGY, 9.
MLA Huang, Zhilin,et al."Circadian Rhythm Dysfunction Accelerates Disease Progression in a Mouse Model With Amyotrophic Lateral Sclerosis".FRONTIERS IN NEUROLOGY 9(2018).
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