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Hepatocyte co-culture in alginate hydrogel for anti-cancer drug analysis
Chin L.K.; Luo K.Q.; Liu A.Q.
2011-12-01
Conference Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Source Publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume3
Pages1499-1501
Conference DateOctober 2-6, 2011
Conference PlaceSeattle, Washington, USA.
CountryUSA
Abstract

This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis.

KeywordCo-culture Drug Analysis Hepatocyte Hydrogel
URLView the original
Language英語English
Fulltext Access
Document TypeConference paper
CollectionFaculty of Health Sciences
Corresponding AuthorLiu A.Q.
AffiliationNanyang Technological University
Recommended Citation
GB/T 7714
Chin L.K.,Luo K.Q.,Liu A.Q.. Hepatocyte co-culture in alginate hydrogel for anti-cancer drug analysis[C], 2011, 1499-1501.
APA Chin L.K.., Luo K.Q.., & Liu A.Q. (2011). Hepatocyte co-culture in alginate hydrogel for anti-cancer drug analysis. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 3, 1499-1501.
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