Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis

doi:10.1109/MEMSYS.2012.6170309

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	Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis
	Chin L.K.1; Luo K.Q.1 ; Park W.2; Je M.2; Tsai J.2; Kwong D.L.2; Liu A.Q.1
	2012-05-07
Conference Name	25th IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Source Publication	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Pages	808-811
Conference Date	JAN 29-FEB 02, 2012
Conference Place	Paris, France
Abstract	This paper presents the formation of double-layer cellular tumor spheroid for the co-culture of hepatocyte (HepG2 cancer liver cell and LO2 normal liver cell) using alginate hydrogel. With the microfluidic chip, double-layer cellular tumor spheroid can be formed by the hydrogel droplet to mimic the in vivo environment in which the cancer cell is surrounded by normal cell. A microchip with concentration gradient generation and tumor spheroid trapping site is designed for anti-cancer drug analysis.
DOI	10.1109/MEMSYS.2012.6170309
URL	View the original
WOS Research Area	Engineering ; Science & Technology - Other Topics
WOS Subject	Engineering, Electrical & Electronic ; Nanoscience & Nanotechnology
WOS ID	WOS:000312912800203
Scopus ID	2-s2.0-84860440137
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Conference paper
Collection	Faculty of Health Sciences
Corresponding Author	Liu A.Q.
Affiliation	1.Nanyang Technological University 2.A-Star, Institute of Microelectronics
Recommended Citation GB/T 7714	Chin L.K.,Luo K.Q.,Park W.,et al. Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis[C], 2012, 808-811.
APA	Chin L.K.., Luo K.Q.., Park W.., Je M.., Tsai J.., Kwong D.L.., & Liu A.Q. (2012). Double-layer hepatocyte tumor co-culture using hydrogel for drug effectivity and specificity analysis. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 808-811.

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