Systems biology of nuclear hormone signaling and gene regulation

UM > Faculty of Health Sciences

Status	已發表Published
	Systems biology of nuclear hormone signaling and gene regulation
	Liu M.H.; Cheung E.
	2012-12-01
Abstract	Nuclear hormone receptors (NR) are sequence-specific signal-regulated transcription factors which control defined patterns of gene expression in a wide variety of physiological and disease processes. The availability of next generation sequencing technologies has generated an extensive amount of information on NR-regulated transcription. Combinatorial approaches in analyzing these datasets has further enhanced our understanding of NR biology and provide alternatives to the prevention, diagnosis and treatment of NR driven diseases. This review will focus on the progress of NR studies through the use of current high-throughput platforms in genomics, transcriptomics and proteomics. We will highlight how the integrative approaches of systems biology have contributed to major progress in our understanding of NR biology through examples from two NR, estrogen receptor α (ERa) and androgen receptor (AR). Together, the large-scale integration of datasets provides us with a network-level understanding of diseases such as cancer that will aid us in predicting drug response and provide therapeutic guides at the general and personalized level. © 2013 by Nova Science Publishers, Inc. All rights reserved.
ISBN	9781619420885;
URL	View the original
Pages	173-198
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Book
Collection	Faculty of Health Sciences
Affiliation	A-Star, Genome Institute of Singapore
Recommended Citation GB/T 7714	Liu M.H.,Cheung E.. Systems biology of nuclear hormone signaling and gene regulation[M], 2012, 173-198.
APA	Liu M.H.., & Cheung E. (2012). Systems biology of nuclear hormone signaling and gene regulation. .

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