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Synergistic anti-tumor effect of a TGFβ inhibitor and cyclophosphamide
Xin Chen1,2; Lalage M. Wakefield3; Joost J. Oppenheim2
2014
Source PublicationOncoimmunology
ISSN2162-4011
Volume3Issue:4
Abstract

In a mouse model of breast carcinoma, the combination of cyclophosphamide and transforming growth factor β1,2,3 (TGFβ1,2,3)-targeting antibody achieved superior antineoplastic effects. This novel paradigm of synergistic chemoimmunotherapy promises to improve the clinical outcome of cancer patients with micrometastases, and thus deserves further investigation.

KeywordAnti-tgfβ Antibody Chemoimmunotherapy Cyclophosphamide
DOI10.4161/onci.28247
Indexed BySCIE
Language英語English
WOS Research AreaOncology ; Immunology
WOS SubjectOncology ; Immunology
WOS IDWOS:000339955700005
Scopus ID2-s2.0-84902590233
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Document TypeJournal article
CollectionUniversity of Macau
Affiliation1.Basic Science Program; Leidos Biomedical Research, Inc.; Frederick National Laboratory for Cancer Research; Frederick, MD USA
2.Laboratory of Molecular Immunoregulation; Cancer Inflammation Program; Center for Cancer Research; National Cancer Institute; Frederick, MD USA
3.Laboratory of Cancer Biology and Genetics; Center for Cancer Research; National Cancer Institute; Frederick, MD USA
Recommended Citation
GB/T 7714		 Xin Chen,Lalage M. Wakefield,Joost J. Oppenheim. Synergistic anti-tumor effect of a TGFβ inhibitor and cyclophosphamide[J]. Oncoimmunology, 2014, 3(4).
APA Xin Chen., Lalage M. Wakefield., & Joost J. Oppenheim (2014). Synergistic anti-tumor effect of a TGFβ inhibitor and cyclophosphamide. Oncoimmunology, 3(4).
MLA Xin Chen,et al."Synergistic anti-tumor effect of a TGFβ inhibitor and cyclophosphamide".Oncoimmunology 3.4(2014).
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