Gene transcription through activation of G-protein-coupled chemoattractant receptors.

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	Gene transcription through activation of G-protein-coupled chemoattractant receptors.
	Ye R.D.; Pan Z.; Kravchenko V.V.; Browning D.D.; Prossnitz E.R.
	1996-10-21
Source Publication	Gene expression
ISSN	10522166
Volume	5 Issue:4-5 Pages:205-215
Abstract	Receptors for leukocyte chemoattractants, including chemokines, are traditionally considered to be responsible for the activation of special leukocyte functions such as chemotaxis, degranulation, and the release of superoxide anions. Recently, these G-protein-coupled serpentine receptors have been found to transduce signals leading to gene transcription and translation in leukocytes. Transcription factors, such as NF kappa B and AP-1, are activated upon stimulation of the cells with several chemoattractants at physiologically relevant concentrations. Activation of transcription factors through these receptors involves G-protein coupling and the activation of protein kinases. The underlying signaling pathways appear to be different from those utilized by TNF-alpha, a better characterized cytokine that induces the transcription of immediate-early genes. Chemoattractants stimulate the expression of several inflammatory cytokines and chemokines, which in turn may activate their respective receptors and initiate an autocrine regulatory mechanism for persistent cytokine and chemokine gene expression.
URL	View the original
Language	英語English
Fulltext Access	View Full-Text via Scopus
Document Type	Journal article
Collection	University of Macau
Affiliation	Scripps Research Institute
Recommended Citation GB/T 7714	Ye R.D.,Pan Z.,Kravchenko V.V.,et al. Gene transcription through activation of G-protein-coupled chemoattractant receptors.[J]. Gene expression, 1996, 5(4-5), 205-215.
APA	Ye R.D.., Pan Z.., Kravchenko V.V.., Browning D.D.., & Prossnitz E.R. (1996). Gene transcription through activation of G-protein-coupled chemoattractant receptors.. Gene expression, 5(4-5), 205-215.
MLA	Ye R.D.,et al."Gene transcription through activation of G-protein-coupled chemoattractant receptors.".Gene expression 5.4-5(1996):205-215.

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