A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

doi:10.2174/1567205012666150504150726

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	已發表Published
	A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation
	Chan S.L.-F.2; Lu L.1; Lam T.L.2; Yan S.-C.2; Leung C.-H.3 ; Ma D.-L.1
	2015
Source Publication	Current Alzheimer Research
ISSN	18755828 15672050
Volume	12 Issue:5 Pages:434-438
Abstract	We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.
Keyword	2-acetylbenzo[b]Thiophen-3-olate Alzheimer's Disease Beta-amyloid Ruthenium(Ii) Tris(2-pyridylmethyl)Amine
DOI	10.2174/1567205012666150504150726
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Neurosciences & Neurology
WOS Subject	Clinical Neurology ; Neurosciences
WOS ID	WOS:000355189000005
Scopus ID	2-s2.0-84930911730
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Chan S.L.-F.
Affiliation	1.Hong Kong Baptist University 2.Hong Kong Polytechnic University 3.University of Macau
Recommended Citation GB/T 7714	Chan S.L.-F.,Lu L.,Lam T.L.,et al. A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation[J]. Current Alzheimer Research, 2015, 12(5), 434-438.
APA	Chan S.L.-F.., Lu L.., Lam T.L.., Yan S.-C.., Leung C.-H.., & Ma D.-L. (2015). A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation. Current Alzheimer Research, 12(5), 434-438.
MLA	Chan S.L.-F.,et al."A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation".Current Alzheimer Research 12.5(2015):434-438.

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