| Residential College | false |
| Status | 已發表Published |
| A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T-Hg2+-T mismatched DNA | |
Wanhe Wang1; Tian-Shu Kang2 ; Philip Wai Hong Chan3,4; Jin-Jian Lu2 ; Xiu-Ping Chen2; Chung-Hang Leung2 ; Dik-Lung Ma1,5
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| 2015-11-17 | |
| Source Publication | Science and Technology of Advanced Materials
 |
| ISSN | 14686996 |
| Volume | 16Issue:6 |
| Abstract | We report herein the use of an exonuclease III and G-quadruplex probe to construct a G-quadruplex-based luminescence detection platform for Hg2+. Unlike common DNA-based Hg2+ detection methods, when using the dsDNA probe to monitor the hairpin formation, the intercalation of the dsDNA probe may be influenced by the distortion of dsDNA. This 'mix-and-detect' methodology utilized the G-quadruplex probe as the signal transducer and is simple, rapid, convenient to use and can detect down to 20 nM of Hg2+. |
| Keyword | Exonuclease Iii G-quadruplex Iridium(Iii) Mercury(Ii) Ion |
| DOI | 10.1088/1468-6996/16/6/065004 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Multidisciplinary |
| WOS ID | WOS:000368333800004 |
| Scopus ID | 2-s2.0-84950311188 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) Institute of Chinese Medical Sciences DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | Chung-Hang Leung; Dik-Lung Ma |
| Affiliation | 1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China 3.School of Chemistry, Monash University, Clayton, Victoria 3800, Australia 4.Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK 5.Partner State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, China |
| Corresponding Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Wanhe Wang,Tian-Shu Kang,Philip Wai Hong Chan,et al. A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T-Hg2+-T mismatched DNA[J]. Science and Technology of Advanced Materials, 2015, 16(6). |
| APA | Wanhe Wang., Tian-Shu Kang., Philip Wai Hong Chan., Jin-Jian Lu., Xiu-Ping Chen., Chung-Hang Leung., & Dik-Lung Ma (2015). A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T-Hg2+-T mismatched DNA. Science and Technology of Advanced Materials, 16(6). |
| MLA | Wanhe Wang,et al."A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T-Hg2+-T mismatched DNA".Science and Technology of Advanced Materials 16.6(2015). |
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