Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction

doi:10.1039/c6cc01079b

UM > Institute of Chinese Medical Sciences

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	Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction
	Zhong H.-J.4; Lee B.R.1; Boyle J.W.1; Wang W.2; Ma D.-L.2; Hong Chan P.W.1; Leung C.-H.4
	2016-04-30
Source Publication	Chemical Communications
ISSN	1364548X 13597345
Volume	52 Issue:34 Pages:5788-5791
Abstract	The natural product-like compound 1 was identified as a direct inhibitor of the menin-MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.
DOI	10.1039/c6cc01079b
URL	View the original
Indexed By	SCIE
WOS Research Area	Chemistry
WOS Subject	Chemistry, Multidisciplinary
WOS ID	WOS:000374396500002
Scopus ID	2-s2.0-84966289652
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Affiliation	1.Monash University 2.Hong Kong Baptist University 3.The University of Warwick 4.University of Macau
First Author Affilication	University of Macau
Recommended Citation GB/T 7714	Zhong H.-J.,Lee B.R.,Boyle J.W.,et al. Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction[J]. Chemical Communications, 2016, 52(34), 5788-5791.
APA	Zhong H.-J.., Lee B.R.., Boyle J.W.., Wang W.., Ma D.-L.., Hong Chan P.W.., & Leung C.-H. (2016). Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction. Chemical Communications, 52(34), 5788-5791.
MLA	Zhong H.-J.,et al."Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction".Chemical Communications 52.34(2016):5788-5791.

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