A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis

doi:10.1021/acsmacrolett.6b00182

UM > Institute of Chinese Medical Sciences

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	A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis
	Li Q.1 ; Guo G.2; Meng F.1 ; Wang H.H.1; Niu Y.1 ; Zhang Q.1 ; Zhang J.2; Wang Y.1 ; Dong L.2; Wang C.1
	2016-05-03
Source Publication	ACS Macro Letters
Volume	5 Issue:5 Pages:617-621
Abstract	We herein report the discovery of a naturally derived carbohydrate with binding affinities for two pro-angiogenic growth factors-fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-BB (PDGF-BB). This galacturonic acid-containing polysaccharide (EUP3) sequestered endogenous FGF-2 and PDGF-BB in vivo and promoted in situ formation and maturation of new blood vessels. Our findings suggest EUP3 as the first nonglycosaminoglycan, nonanimal-originated carbohydrate molecule that binds two pro-angiogenic growth factors to stimulate angiogenesis. Further investigations into this carbohydrate may lead to the development of new tools for therapeutic angiogenesis.
DOI	10.1021/acsmacrolett.6b00182
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Polymer Science
WOS Subject	Polymer Science
WOS ID	WOS:000376225800014
The Source to Article	Scopus
Scopus ID	2-s2.0-84969802808
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Dong L.; Wang C.
Affiliation	1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 2.State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210093, China
First Author Affilication	Institute of Chinese Medical Sciences
Corresponding Author Affilication	Institute of Chinese Medical Sciences
Recommended Citation GB/T 7714	Li Q.,Guo G.,Meng F.,et al. A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis[J]. ACS Macro Letters, 2016, 5(5), 617-621.
APA	Li Q.., Guo G.., Meng F.., Wang H.H.., Niu Y.., Zhang Q.., Zhang J.., Wang Y.., Dong L.., & Wang C. (2016). A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis. ACS Macro Letters, 5(5), 617-621.
MLA	Li Q.,et al."A Naturally Derived, Growth Factor-Binding Polysaccharide for Therapeutic Angiogenesis".ACS Macro Letters 5.5(2016):617-621.

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