In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum

doi:10.1055/s-0030-1250030

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	In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum
	Ai-Lin Liu 1; Fan Yang 1; Mian Zhu 1; Dan Zhou 1; Mao Lin 2; Simon Ming-Yuen Lee3 ; Yi-Tao Wang3 ; Guan-Hua Du 1
	2010
Source Publication	Planta Medica
Volume	76 Issue:16 Pages:1874
Abstract	The anti-influenza viral activities of six stilbenoids from the lianas of Gnetum pendulum C.Y. Cheng were evaluated with two different assays, neuraminidase (NA) activity assay and cytopathic effect (CPE) reduction assay. The NA assay results showed that all six stilbenoids exerted an NA inhibitory effect, while the CPE assay indicated that among them, isorhapontigenin (2), gnetupendin B (3), shegansu B (4), and gnetin D (6) exhibit significant in vitro anti-influenza viral activity in MDCK cells, with IC50 values from 0.67 to 11.99μg/mL in comparison to the positive controls oseltamivir acid and ribavirin whose IC50 values were 0.040 and 5.54μg/mL, respectively. © Georg Thieme Verlag KG Stuttgart · New York.
Keyword	Gnetaceae Gnetum Pendulum Influenza Virus Neuraminidase Stilbenoid
DOI	10.1055/s-0030-1250030
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
WOS Subject	Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
WOS ID	WOS:000284144400016
The Source to Article	Scopus
Scopus ID	2-s2.0-78349253876
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	DEPARTMENT OF PHARMACEUTICAL SCIENCES Institute of Chinese Medical Sciences
Corresponding Author	Simon Ming-Yuen Lee
Affiliation	1.Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, 1 Xian Nong Tan Street, 100050 Beijing, China 2.Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Beijing, China 3.Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira S. J., Taipa, Macao, China
Corresponding Author Affilication	Institute of Chinese Medical Sciences
Recommended Citation GB/T 7714	Ai-Lin Liu,Fan Yang,Mian Zhu,et al. In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum[J]. Planta Medica, 2010, 76(16), 1874.
APA	Ai-Lin Liu., Fan Yang., Mian Zhu., Dan Zhou., Mao Lin., Simon Ming-Yuen Lee., Yi-Tao Wang., & Guan-Hua Du (2010). In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum. Planta Medica, 76(16), 1874.
MLA	Ai-Lin Liu,et al."In vitro anti-influenza viral activities of stilbenoids from the lianas of Gnetum pendulum".Planta Medica 76.16(2010):1874.

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