Versatile metal graphitic nanocapsules have aroused extensive research interest in biomedicine due to their superior stability, good biocompatibility and unique physicochemical properties. Based on the unique Raman scattering characteristic peaks of the graphitic shell as a Raman label or internal standard, combining the superior surface enhanced Raman scattering(SERS) and two-photon luminescence(TPL) performance of the plasmonic nanocore, SERS bioanalysis and Raman/TPL dual-modal imaging of tumor cells or tissues have been realized. Based on the graphitic shell with large specific surface area as the drugs loading platform, combining the near⁃infrared light absorption capacity of the plasmonic nanocore, light-mediated pathogen killing and synergistic hyperthermia and chemotherapy of cancer cells or solid tumors have been realized. In addition, fluorescence detection of biomolecules has been realized based on the excellent fluorescence quenching performance of the graphitic shell; separation and enrichment of biological samples, in-situ magne-tic resonance imaging detection of bacteria and magnetic targeted oral drug delivery in stomach have been rea-lized based on the unique magnetic properties of magnetic nanocore. This review firstly introduces the preparation, classification and properties of metal graphitic nanocapsules, then outlines the recent progress of their extensive applications in biodetection, bioimaging and therapy, and further summarizes their development status including biotoxicity study and pros, cons in biomedicine, their future prospects in biomedical applications are eventually highlighted. We expect the versatile metal graphitic nanocapsules will offer a robust nanoplatform for future clinical biomedical applications.