This article develops a high-swing 64-Gb/s four-level pulse amplitude modulation (PAM-4) transmitter (TX) implemented in a 28-nm CMOS process. The proposed 4-tap hybrid feed-forward equalization (FFE) employs the fractionally-spaced pre-emphasis (FS-PE) and the baud-spaced de-emphasis (BS-DE). The PE-based FFE enlarges the output swing by directly stacking the distorted pulses, and it naturally consumes less power as it only boosts the desired distorted symbols. Additionally, the FS-based FFE provides a compensation for high-frequency loss beyond f N yquist and the post2 tap equalizes the low-frequency channel loss, which could match the channel attenuation accurately. Combining both the FS-PE-based pre/post1 taps and BS-DE-based post2 tap, the proposed TX achieves a differential output swing of 1.4 Vppd and an energy efficiency of 1.53 pJ/bit, and the eye height and eye width are 198 mV and 0.48 UI at the data rate of 64 Gb/s.