Liquid food containers commonly suffer from inevitable contamination and even biofilm formation due to the adhesion of food residuals or saliva, which requires detergents to clean. Although previously reported superhydrophobic and omniphobic coatings can resist the adhesion of liquids, the requirements of specific nanostructures or infused lubricants limit their applications in food containers. Here, by grafting smooth glass containers with “liquid like” polydimethylsiloxane brushes, we developed a unique approach for preparing a slippery coating that could exhibit highly robust repellency to various liquid foods. The coating was highly transparent and did not induce a significant alteration of the smooth surface. The “liquid like” coating could effectively prevent the adhesion of various liquid foods and inhibit the formation of bacterial biofilms, without the use of detergents for cleaning. Moreover, this coating could resist mechanical damage from friction, and displayed high biocompatibility with biological cells. The slipperiness, smoothness, robustness and biocompatibility of the “liquid like” coating was highly beneficial to practical applications as self-cleaning glass container, which has been challenging to achieve by conventional superhydrophobic or omniphobic coatings. Our study introduced a versatile strategy to functionalize biocompatible surfaces for food containers which reduced the contamination of residues and the use of detergents, and may be beneficial to human and environmental health.