Multi-focus image fusion aims to generate an image with all objects in focus by integrating multiple partially focused images. It is challenging to find an effective focus measure to evaluate the clarity of source images. In this paper, a novel multi-focus image fusion algorithm based on Geometrical Sparse Representation (GSR) over single images is proposed. The main novelty of this work is that it shows the potential of GSR coefficients used for image fusion. Unlike the traditional sparse representation-based (SR) methods, the proposed algorithm does not need to train an overcomplete dictionary and vectorize the signal. In our algorithm, using a single dictionary image, the source images are first represented by geometrical sparse coefficients. Specifically, we employ a weighted GSR model in the sparse coding phase, ensuring the importance of the center pixel. Then, the weighted GSR coefficient is used to measure the activity level of the source image and an average pooling strategy is applied to obtain an initial decision map. Third, the decision map is refined with a simple post-processing. Finally, the fused all-in-focus image is constructed with the refined decision map. Experimental results demonstrate that the proposed method can be competitive with or even superior to the state-of-the-art fusion methods in both subjective and objective comparisons.