Oilfield flow assurance is the subject to study the impact on the flow of production fluids due to physicochemical changes in the production system. Mineral scale deposition is among the top 3 water-related flow assurance challenges in petroleum industry, particularly for offshore and shale operations. Scale deposition can lead to serious operational risks and significant financial loss. The most commonly adopted strategy in oilfield scale control is the deployment of chemical inhibitors. Although conventional chemical inhibitors are effective in inhibiting scale threat, they have the drawbacks of short transport distance and limited squeeze lifetime due to their intrinsic chemical properties. In the past decade, as an alternative to conventional chemical inhibition, research efforts have been made to prepare functional nanomaterials with different chemical compositions to overcome the drawbacks of conventional chemical inhibitors. These synthesized nanomaterials can serve as delivery vehicles to deploy inhibitors into the target location in the production system. These nanomaterials are reported to have multiple advantages over the conventional inhibitors in terms of transportability, controlled release, and functionality, evidenced by a series of experimental studies. This review presents an overview of scale inhibitor nanomaterial development and the current methods to synthesize and to evaluate these nanomaterials in a systematic and comprehensive manner. This review focuses on the chemistry principles and methodologies underlying inhibitor nanomaterial synthesis and also the chemical instrument and strategies in evaluating the physiochemical properties of these materials in terms of inhibition effectiveness, transportability, and inhibitor return. The scale inhibitor nanomaterials (SINMs) presented in this review exemplify the continuous development in our capabilities in adopting novel nanotechnology in combating actual engineering challenges in petroleum industry.