As the fifth-generation (5G) mobile communication technology captures public attention, reviewing the first to fourth generations with the anticipated implications of 5G and afterward, and future research would present a useful value to the literature. This study uses a systematic content analysis methodology to provide a comprehensive and interdisciplinary review of mobile communication research in tourism and hospitality to help academic researchers and industry practitioners understand the research area. The study also analyzes the future changes that mobile communication technologies and their applications will bring to tourism and hospitality research trends and industry practices. This study not only contributes to identifying some research gaps in the extant research, but can also provide significant theoretical guidance and practical implications for further academic and industrial research related to mobile communication technologies in tourism and hospitality.