| Residential College | false |
| Status | 已發表Published |
| An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator | |
Liu L.-J.1; Lu L.2; Zhong H.-J.1; He B.2; Kwong D.W.J.2; Ma D.-L.2 ; Leung C.-H.1
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| 2015 | |
| Source Publication | Journal of Medicinal Chemistry
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| ISSN | 222623 |
| Volume | 58Issue:16Pages:6697 |
| Abstract | A novel iridium(III) complex was synthesized and evaluated for its ability to target JMJD2 enzymatic activity. The iridium(III) complex 1 can inhibit JMJD2 activity and was selective for JMJD2 activity over JARID, JMJD3, and HDAC activities. Moreover, 1 suppressed the trimethylation of the p21 promoter on H3K9me3 and interrupted the JMJD2D-H3K9me3 interactions in human cells, suggesting that it could act as an epigenetic modulator. To our knowledge, 1 represents the first metal-based JMJD2 inhibitor reported in the literature. (Figure Presented). © 2015 American Chemical Society. |
| DOI | 10.1021/acs.jmedchem.5b00375 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal |
| WOS ID | WOS:000360415800029 |
| The Source to Article | Scopus |
| Scopus ID | 2-s2.0-84940539379 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Ma D.-L.; Leung C.-H. |
| Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao P. R. China 2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong P. R. China |
| First Author Affilication | Institute of Chinese Medical Sciences |
| Corresponding Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Liu L.-J.,Lu L.,Zhong H.-J.,et al. An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator[J]. Journal of Medicinal Chemistry, 2015, 58(16), 6697. |
| APA | Liu L.-J.., Lu L.., Zhong H.-J.., He B.., Kwong D.W.J.., Ma D.-L.., & Leung C.-H. (2015). An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator. Journal of Medicinal Chemistry, 58(16), 6697. |
| MLA | Liu L.-J.,et al."An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator".Journal of Medicinal Chemistry 58.16(2015):6697. |
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