This paper proposes a region kernel to measure the region-to-region distance similarity for hyperspectral image (HSI) classification. The region kernel is designed to be a linear combination of multiscale box kernels, which can handle the HSI regions with arbitrary shape and size. Integrating labeled pixels and labeled regions, we further propose a region-kernel-based support vector machine (RKSVM) classification framework. In RKSVM, three different composite kernels are constructed to describe the joint spatial-spectral similarity. Particularly, we design a desirable stack composite kernel that consists of the point-based kernel, the region-based kernel, and the cross point-to-region kernel. The effectiveness of the proposed RKSVM is validated on three benchmark hyperspectral data sets. Experimental results show the superiority of our region kernel method over the classical point kernel methods. © 1980-2012 IEEE.