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A natural product-like inhibitor of NEDD8-activating enzyme
Chung-Hang Leung1; Daniel Shiu-Hin Chan2; Hui Yang2; Ruben Abagyan3; Simon Ming-Yuen Lee4; Guo-Yuan Zhu1; Wang-Fun Fong1; Dik-Lung Ma2
2011
Source PublicationChemical Communications
ISSN13597345
Volume47Issue:9Pages:2511
Abstract

The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range. © 2011 The Royal Society of Chemistry.

DOI10.1039/c0cc04927a
URLView the original
Language英語English
WOS IDWOS:000287409800004
The Source to ArticleScopus
Scopus ID2-s2.0-79952261355
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Document TypeJournal article
CollectionDEPARTMENT OF PHARMACEUTICAL SCIENCES
Institute of Chinese Medical Sciences
Affiliation1.Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong
3.Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, USA
4.Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomás Pereira S.J., Taipa, Macao, China
Recommended Citation
GB/T 7714
Chung-Hang Leung,Daniel Shiu-Hin Chan,Hui Yang,et al. A natural product-like inhibitor of NEDD8-activating enzyme[J]. Chemical Communications, 2011, 47(9), 2511.
APA Chung-Hang Leung., Daniel Shiu-Hin Chan., Hui Yang., Ruben Abagyan., Simon Ming-Yuen Lee., Guo-Yuan Zhu., Wang-Fun Fong., & Dik-Lung Ma (2011). A natural product-like inhibitor of NEDD8-activating enzyme. Chemical Communications, 47(9), 2511.
MLA Chung-Hang Leung,et al."A natural product-like inhibitor of NEDD8-activating enzyme".Chemical Communications 47.9(2011):2511.
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