To commemorate the 50th anniversary of the IEEE Transactions on Systems, Man, and Cybernetics: Systems, this article examines and reports on its past to current topical coverage of systems science and engineering toward exploring the evolving focus of the research community. Results of a systematic bibliometric analysis are presented with associated conclusions, implications, and summary of topical areas. In addition, respective views regarding the current state of the field and where it is headed are offered by recent leaders of the IEEE Systems, Man, and Cybernetics Society, including its continued relevance and role in the advancement of systems technology.