| Residential College | false |
| Status | 已發表Published |
| Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe | |
Leung K.-H.1; He H.-Z.1; Ma V.P.-Y.1; Zhong H.-J.2 ; Chan D.S.-H.1; Zhou J.3,4; Mergny J.-L.3,4; Leung C.-H.2  ; Ma D.-L.1
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| 2013 | |
| Source Publication | Chemical Communications
 |
| ISSN | 13597345 |
| Volume | 49Issue:50Pages:5630 |
| Abstract | We report herein a simple and convenient luminescent assay for detection of base excision repair enzyme activity using an Ir(iii) complex as a G-quadruplex selective probe. Using uracil-DNA glycosylase (UDG) as a model enzyme, the assay achieved high sensitivity and selectivity for UDG over other tested enzymes. The utility of the assay for screening potential UDG inhibitors was also demonstrated. © 2013 The Royal Society of Chemistry. |
| Keyword | Dna Mismatch Repair Complexes Mechanisms Assay |
| DOI | 10.1039/c3cc41129j |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000319511900003 |
| Publisher | ROYAL SOC CHEMISTRYTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND |
| The Source to Article | Scopus |
| Scopus ID | 2-s2.0-84878659357 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Leung C.-H.; Ma D.-L. |
| Affiliation | 1.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China 3.INSERM, U869, IECB, F-33600, Pessac, France 4.Univ. Bordeaux, ARNA Laboratory, F-33000, Bordeaux, France |
| Corresponding Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Leung K.-H.,He H.-Z.,Ma V.P.-Y.,et al. Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe[J]. Chemical Communications, 2013, 49(50), 5630. |
| APA | Leung K.-H.., He H.-Z.., Ma V.P.-Y.., Zhong H.-J.., Chan D.S.-H.., Zhou J.., Mergny J.-L.., Leung C.-H.., & Ma D.-L. (2013). Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe. Chemical Communications, 49(50), 5630. |
| MLA | Leung K.-H.,et al."Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe".Chemical Communications 49.50(2013):5630. |
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