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Medication use during pregnancy in mainland china: A cross-sectional analysis of a national health insurance database
Zhang,Jingyuan1; Ung,Carolina Oi Lam2; Wagner,Anita Katharina3; Guan,Xiaodong1,3,4; Shi,Luwen1,4
2019
Source PublicationClinical Epidemiology
Volume11Pages:1057-1065
Abstract

Purpose: This study aims to illustrate the prevalence and patterns of medication use among pregnant women in mainland China. Patients and methods: Hospital and drugstore service data for a nationally representative sample of basic medical insurance (BMI) beneficiaries in 2015 were obtained from the China Health Insurance Association (CHIRA) database. A total of 7946 women who had singleton deliveries in 2015, aged between 12 and 54, and whose records in the CHIRA database covered at least one trimester were included in this study. We conducted descriptive analyses of sample characteristics, medication use prevalence, and number and types of medications used. Results: We found that 11.7% of women used at least one medication during the course of pregnancy (median number of medications used = 6.7). Medication use was more common among those who were older, residing in Eastern China, or employed. Most commonly used medication groups by the Anatomical Therapeutic Chemical Classification System were B (Blood and blood forming organs, 49.3%), A (Alimentary tract and metabolism, 48.1%), G (Genito urinary system and sex hormones, 38.1%) and J (Antiinfectives for systemic use, 31.6%). Intravenous solutions, vitamins and minerals, progestogens, and beta-lactam antibacter-ials were the most frequently used medications from each of these four ATC groups, respectively. Moreover, 7.1% used at least one medication contraindicated in pregnancy. Conclusion: This study showed that around one in 10 women used medication during pregnancy in mainland China and found possible cases of inappropriate or unsafe medication use.

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Purpose: This study aims to illustrate the prevalence and patterns of medication use among pregnant women in mainland China. Patients and methods: Hospital and drugstore service data for a nationally representative sample of basic medical insurance (BMI) beneficiaries in 2015 were obtained from the China Health Insurance Association (CHIRA) database. A total of 7946 women who had singleton deliveries in 2015, aged between 12 and 54, and whose records in the CHIRA database covered at least one trimester were included in this study. We conducted descriptive analyses of sample characteristics, medication use prevalence, and number and types of medications used. Results: We found that 11.7% of women used at least one medication during the course of pregnancy (median number of medications used = 6.7). Medication use was more common among those who were older, residing in Eastern China, or employed. Most commonly used medication groups by the Anatomical Therapeutic Chemical Classification System were B (Blood and blood forming organs, 49.3%), A (Alimentary tract and metabolism, 48.1%), G (Genito urinary system and sex hormones, 38.1%) and J (Antiinfectives for systemic use, 31.6%). Intravenous solutions, vitamins and minerals, progestogens, and beta-lactam antibacter-ials were the most frequently used medications from each of these four ATC groups, respectively. Moreover, 7.1% used at least one medication contraindicated in pregnancy. Conclusion: This study showed that around one in 10 women used medication during pregnancy in mainland China and found possible cases of inappropriate or unsafe medication use.

KeywordChina Cross-sectional Health Insurance Database Medication Use Pregnancy China Cross-sectional Health Insurance Database Medication Use Pregnancy
DOI10.2147/CLEP.S230589
URLView the original
Indexed BySCIE
WOS Research AreaPublic, Environmental & Occupational Health ; Public, Environmental & Occupational Health
WOS SubjectPublic, Environmental & Occupational Health ; Public, Environmental & Occupational Health
WOS IDWOS:000504891200001
Scopus ID2-s2.0-85078559888
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorShi,Luwen
Affiliation1.Department of Pharmacy Administration and Clinical Pharmacy,School of Pharmaceutical Sciences,Peking University,Beijing,China
2.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Macao,Macao
3.Department of Population Medicine,Harvard Medical School,Harvard Pilgrim Health Care Institute,Boston,United States
4.International Research Center for Medicinal Administration,Peking University,Beijing,China
Recommended Citation
GB/T 7714
Zhang,Jingyuan,Ung,Carolina Oi Lam,Wagner,Anita Katharina,et al. Medication use during pregnancy in mainland china: A cross-sectional analysis of a national health insurance database[J]. Clinical Epidemiology, 2019, 11, 1057-1065.
APA Zhang,Jingyuan., Ung,Carolina Oi Lam., Wagner,Anita Katharina., Guan,Xiaodong., & Shi,Luwen (2019). Medication use during pregnancy in mainland china: A cross-sectional analysis of a national health insurance database. Clinical Epidemiology, 11, 1057-1065.
MLA Zhang,Jingyuan,et al."Medication use during pregnancy in mainland china: A cross-sectional analysis of a national health insurance database".Clinical Epidemiology 11(2019):1057-1065.
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