Residential College | false |
Status | 已發表Published |
Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities | |
Xu Z.1,2; Chen X.1; Zhong Z.1; Chen L.2; Wang Y.1 | |
2011 | |
Source Publication | American Journal of Chinese Medicine |
ISSN | 0192415X |
Volume | 39Issue:1Pages:15 |
Abstract | Ganoderma lucidum (G. lucidum), a basidiomycete white rot fungus, has long been prescribed to prevent and treat various human diseases, particularly in China, Japan, and Korea. Several classes of bioactive substances have been isolated and identified from G. lucidum, such as triterpenoids, polysaccharides, nucleosides, sterols, and alkaloids, among others. This paper examines the potential role of G. lucidum polysaccharide (GLPS) in tumor therapy and the possible mechanisms involved. Both in vitro and in vivo studies suggested that the anti-tumor activities of GLPS are mediated by its immunomodulatory, anti-angiogenic, and cytotoxic effects. GLPS affects immune cells and immune-related cells including B lymphocytes, T lymphocytes, dendritic cells, macrophages, and natural killer cells. In addition, recent data also suggest that GLPS suppresses tumorigenesis or inhibits tumor growth through direct cytotoxic effect and anti-angiogenic actions. However, many questions still need to be answered before both G. lucidum and GLPS can be widely accepted and used as anti-tumor agents. © 2011 World Scientific Publishing Company & Institute for Advanced Research in Asian Science and Medicine. |
Keyword | Anti-angiogenesis Anti-proliferation Ganoderma Lucidum Immunomodulation Polysaccharides |
DOI | 10.1142/S0192415X11008610 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Integrative & Complementary Medicine ; General & Internal Medicine |
WOS Subject | Integrative & Complementary Medicine ; Medicine, General & Internal |
WOS ID | WOS:000287004800002 |
The Source to Article | Scopus |
Scopus ID | 2-s2.0-78751493724 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | Institute of Chinese Medical Sciences |
Affiliation | 1.Institute of Chinese Medical Sciences University of Macau, Macau, P. R. China 2.Department of Pharmacy Fujian University of Traditional Chinese Medicine Fuzhou, P. R. China |
First Author Affilication | Institute of Chinese Medical Sciences |
Recommended Citation GB/T 7714 | Xu Z.,Chen X.,Zhong Z.,et al. Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities[J]. American Journal of Chinese Medicine, 2011, 39(1), 15. |
APA | Xu Z.., Chen X.., Zhong Z.., Chen L.., & Wang Y. (2011). Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities. American Journal of Chinese Medicine, 39(1), 15. |
MLA | Xu Z.,et al."Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities".American Journal of Chinese Medicine 39.1(2011):15. |
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