| Residential College | false |
| Status | 已發表Published |
| Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1β inhibitors | |
Xu,Yunshao1 ; Zhang,Tian1; Feng,Lu2; Feng,Zheling1; Zhang,Qingwen1 ; Ye,Yang2,3; Gan,Lishe4 ; Lin,Ligen1
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| 2021-04 | |
| Source Publication | CHINESE CHEMICAL LETTERS
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| ISSN | 1001-8417 |
| Volume | 32Issue:4Pages:1475-1479 |
| Abstract | To search naturally occurring interleukin-1β (IL-1β) inhibitors, biscaesalmins A (1) and B (2), two highly oxidized dimeric cassane diterpenoids with a newly formed alicyclic skeleton, have been isolated from the traditional Chinese medicine Kushilian (Caesalpinia minax). Their full structures were determined by comprehensive spectroscopic analysis and quantum chemical TD-DFT (time-dependent density functional theory) calculation. Biosynthetically, 1 and 2 were formed via an intermolecular [4 + 2] Diels-Alder cycloaddition of two monomers, affording an additional six-membered carbon ring linkage. Compounds 1 and 2 inhibited nitric oxide production on lipopolysaccharide-stimulated THP-1 macrophages, with IC values being at 1.20 ± 0.23 and 2.30 ± 0.15 μmol/L, respectively. Furthermore, compound 1 inhibited NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome-mediated IL-1β production and blocked the migration of macrophages towards adipocyte conditioned medium. Biscaesalmins A and B might be candidates for treating inflammation-related metabolic diseases. |
| Keyword | Caesalpinia Minax Dimeric Cassane Diterpenoids Il-1β Nlrp3 Td-dft |
| DOI | 10.1016/j.cclet.2020.09.048 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Multidisciplinary |
| WOS ID | WOS:000644727600006 |
| Publisher | ELSEVIER SCIENCE INCSTE 800, 230 PARK AVE, NEW YORK, NY 10169 |
| Scopus ID | 2-s2.0-85095818341 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences THE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU) |
| Corresponding Author | Gan,Lishe; Lin,Ligen |
| Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Avenida da Universidade,999078,China 2.State Key Laboratory of Drug Research,& Natural Products Chemistry Department,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai,201203,China 3.School of Life Science and Technology,Shanghai Tech University,Shanghai,201203,China 4.School of Biotechnology and Health Sciences,Wuyi University,Jiangmen,529020,China |
| First Author Affilication | Institute of Chinese Medical Sciences |
| Corresponding Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Xu,Yunshao,Zhang,Tian,Feng,Lu,et al. Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1β inhibitors[J]. CHINESE CHEMICAL LETTERS, 2021, 32(4), 1475-1479. |
| APA | Xu,Yunshao., Zhang,Tian., Feng,Lu., Feng,Zheling., Zhang,Qingwen., Ye,Yang., Gan,Lishe., & Lin,Ligen (2021). Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1β inhibitors. CHINESE CHEMICAL LETTERS, 32(4), 1475-1479. |
| MLA | Xu,Yunshao,et al."Biscaesalmins A and B from Caesalpinia minax, highly oxidized dimeric cassane diterpenoids as interleukin-1β inhibitors".CHINESE CHEMICAL LETTERS 32.4(2021):1475-1479. |
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