Objective: To predict the shelf life of Chinese Angelica by investigating the stability of its active components. Method: The classic homeothermia method was used for forecast the shelf life, and HPLC was applied for quantitative determination of chemical compounds in Chinese Angelica. Result: The correlation equations, thermal constant at ambient temperature (k) and shelf life (t) for coniferyl ferulate and Z-Ligustilide were Igk = -5 152.1/T + 13.8 (r = 0.9985), 3.33 × 10, 13 d and Igk = -4 064.6/T + 10.4 (r = 0.999 7), 5.91 × 10, 7 d, respectively. Conclusion: The shelf life of Chinese Angelica has been established, which suggests that it is very important for ensuring the safety and efficacy of Chinese crude drug.